About this Research Topic
The alternative regenerative medicine approach aims to explore the post-embryonic regeneration of tissues, such as the pancreas, as a therapeutic application option for a variety of diseases. Post-embryonic regeneration of tissue applies to the liver, kidney, peripheral tissues (i.e., wound healing), and others.
Many examples of tissues regeneration without soliciting stem cells exist. For example, a salamander is regenerating lost limbs without soliciting stem cell intervention. These findings give possible strategies for tissues repair in humans, beyond stem cell-based approaches. Liver regeneration following partial hepatectomy is carried out by the participation of all mature liver cell types. We demonstrated through our novel biologic approach that integrates multiple levels of somatic cellular physiology to regulate regenerative organ capacity without stem cell via a post-embryonic mechanism. This new field of research has been coined as “Cellular Networking Integration & Processing (CNIP).”
The fundamental principle underlying CNIP is to simultaneously target and integrate three key levels of metabolic and cellular control: (1) glucose metabolism; (2) activation of tyrosine kinase receptors; and (3) gene expression that has been implicated in beta cell formation in vivo. In our previous study conducted in 2016, a lentiviral construct expressing a cocktail of molecules acting at the three key levels of metabolic and cellular control was injected into the pancreatic duct via a catheter in the partially pancreatectomized mouse model of diabetes. This study demonstrated that CNIP (i) induced pancreatic beta-cell formation in adult animals in vivo and (ii) normalized fasting and post-prandial blood glucose and plasma insulin concentrations without hypoglycemia. The CNIP approach is a proof of concept of regenerative medicine to induce insulin-producing cells in the adult pancreas, beyond the stem cell-based approach.
The CNIP approach, which targets the post-embryonic regenerative capacity of tissues represents an alternative approach in regenerative medicine and is the focus of this Research Topic. This Research Topic opens the door to investigators, beyond diabetes researchers, to highlight their work on salamander regenerative capacity, liver regeneration, etc. The goal of this Research Topic is to create a platform that promotes cross-pollination between fundamental and translational research in regenerative medicine and to create emulations that bring solutions to major tissue and organ damage by the complication in a diabetic subject to alternative regenerative medicine.
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