About this Research Topic
Adaptor proteins play a critical role in the integration of multiple signalling mediators and the propagation of signal transduction implicated in diverse range of cellular processes. They function as docking molecular platforms, bring effector molecules into close proximity to their targets and regulate cellular functions by mediating constitutive or inducible protein-protein/lipid interactions via specific modular domains. These domains, often multiple, bind and recruit other molecules and facilitate the formation of macromolecular signalling complexes. Emerging studies have identified a number of adaptor proteins that coordinate signalling pathways implicated in various immunological processes, including lymphocyte migration, activation, differentiation and effector functions. Understanding the mechanisms by which adaptor proteins regulate immune signalling will reveal the molecular network of complex signalling pathways and allow the identification of critical regulatory steps in specific signal transduction cascades. Furthermore, understanding the interactions between adaptor proteins and signalling molecules could help to identify selective targets for novel therapeutic agents.
This Research Topic will highlight the recent discovery and advances of the understanding of adaptor protein involvement in health and diseases. We aim to provide a comprehensive overview of various adaptor proteins and their multi-factorial involvement in immune signalling from basic research to clinical translation. Potential topics include, but are not limited to the following areas:
1. Role of adaptor proteins in regulating the activation and effector functions of innate and adaptive immune cells.
2. Role of adaptor proteins in the migration of innate and adaptive immune cells.
3. Adaptor proteins mediating ligand/receptor-induced molecular crosstalk.
4. Structural aspects of adaptor proteins.
5. Mechanisms of adaptor protein-mediated immunological processes.
6. Crosstalk of adaptor proteins with other signalling mediators.
7. Non-scaffold functions of adaptor proteins.
8. Adaptor proteins as potential therapeutic targets in immune-mediated diseases.
Research Topic Editor, Prof. Dermot Kelleher is Non-Executive Director of ICON plc. All other Research Topic Editors declare no competing interests with regards to the Research Topic subject.
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