Research Topic

Polydopamine-Based Nanostructures: Synthesis and Biomedical Applications

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About this Research Topic

Polydopamine (PDA) is a versatile polymer inspired by invertebrate mussels due to its extremely high adhesion performance to solid surfaces, and has recently gained attention from research into its multi-functional applications as a coating material. PDA can be deposited on all types of inorganic and organic ...

Polydopamine (PDA) is a versatile polymer inspired by invertebrate mussels due to its extremely high adhesion performance to solid surfaces, and has recently gained attention from research into its multi-functional applications as a coating material. PDA can be deposited on all types of inorganic and organic substrates including metals, oxides, ceramics, polymers, and nanostructure surfaces with controllable thickness and excellent stability.

The synthesis of PDA can be achieved through a solution oxidation method using dopamine as its building blocks. Dopamine can be oxidized and spontaneously self-polymerize under alkaline conditions, with oxygen as the oxidant. Despite the simple synthesis procedure, the molecular mechanism behind PDA formation has still been a topic of scientific debate.

After a decade of study, potential uses of PDA have expanded in many directions. Tailoring surface properties of the PDA open the way to accelerate diversifying and extending potential applications.

This Research Topic welcomes contributions focusing on PDA synthesis and mechanism study, PDA coating method development, PDA-derived hybrid/composite materials preparation and characterization, and the application of PDA-based materials. We encourage the submission of original research articles, reviews, and mini-reviews to this Research Topic. Particularly, we are looking for research articles describing the following:

 1) Fundamental investigation of PDA formation route using experimental or theoretical means.
 2) Development of new coating strategies for PDA deposition with controlled thickness and morphology.
 3) Preparation of new PDA-based composite materials.
 4) Applications of PDA or PDA-based materials in biomedical science such as drug delivery, biosensing, and bioimaging.


Keywords: polydopamine, polymerization mechanism, coatings, composites, biomedical applications


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