About this Research Topic
The immunological community has, in fact, an excellent track record of conducting worldwide cooperative efforts on nomenclature issues. Remarkable examples of these include the establishment of the nomenclature for antigen receptor (IG and TR) genes, cytokines and chemokines and their receptors, as well as allergens, cell types and of the CD nomenclature for monoclonal antibodies.
With the many achievements reached in the past 40 years, there is a wealth of experience to draw upon, especially within the sub-committees of the Nomenclature Committee of the International Union of Immunological Societies (IUIS; www.iuisonline.org). The IUIS Nomenclature Committee is fostering nomenclature efforts by providing a platform that currently includes the activities of altogether 11 nomenclature subcommittees (Nomenclature Committee)
With the present Research Topic, we aim to highlight the need to address controversies and to stress the importance of nomenclature based on consensus within the immunology community. This Research Topic welcomes the submission of Original Research articles, Reviews, Mini-Reviews, Classification and Perspective articles that can provide a (historical) overview, challenge current standards, raise a new/potential issue, and propose new standards, on the following aspects of nomenclature in the immune system:
1. Genes – including, but not restricted to, families of genes or complex loci with important functions in the immune system, such as antigen receptors (IG/TR genes) and HLA/MHC.
2. Proteins including post-translational modifications – including, but not restricted to, families of antigen and pattern recognition receptors, activation/inhibition receptors, cytokines, chemokines and their receptors, and signaling molecules (kinases, phosphatases) and transcription factors involved in regulating lymphocytes and innate immune cells.
3. Cells – including cells of the myeloid and lymphoid lineages, as well as non-haematopoietic mesenchymal stem cells and fibroblasts with defined functions in the immune response.
4. Allergens – including, but not limited to, food and aero-allergens, venoms, and medication.
5. Biological reagents – including but not limited to recombinant proteins, monoclonal antibodies and small molecule inhibitors of protein function.
Articles published within this Research Topic may include suggestions of nomenclature. However, this does not imply that the suggested nomenclature has been approved by the IUIS Nomenclature Committee (http://www.iuisonline.org/index). A nomenclature can be labelled as approved by the IUIS Nomenclature Committee only following official approval by the IUIS Nomenclature Committee. Any questions regarding an official approval of a nomenclature should be directed to the IUIS Nomenclature Chair or the relevant Subcommittee Chair.
We acknowledge the initiation and support of this Research Topic by the International Union of Immunological Societies (IUIS). A/Prof. Menno van Zelm currently serves as the chairman for the IUIS Nomenclature Committee; Prof. Pablo Engel is the chair of the IUIS CD Nomenclature Sub-Committee; Prof. Loems Ziegler-Heitbrock is the chair of the IUIS Monocytes and Dendritic Cells in Blood Sub-Committee; Asst. Prof. Sanny Chan is a member of the WHO / IUIS Allergen Nomenclature Sub-Committee and A/Prof. Andrew Collins is co-chair of the Germline Gene Database (GLDB) Working Group of the Adaptive Immune Receptor Repertoire community (AIRR-C) and chair of the Inferred Allele Review Committee (IARC).
Keywords: immunology, gene, protein, antibody, allergen, society affiliation RT
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