Research Topic

Invasive Fungal Infections: Diagnosis And Treatments

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Diagnosis of fungal infections is the most critical step to determine treatment, infection control, and disease management. Fungal infections are challenging in clinical treatment and their management requires (i) knowledge of their epidemiology, (ii) host characteristics, (iii) diagnostic criteria, and (iv) ...

Diagnosis of fungal infections is the most critical step to determine treatment, infection control, and disease management. Fungal infections are challenging in clinical treatment and their management requires (i) knowledge of their epidemiology, (ii) host characteristics, (iii) diagnostic criteria, and (iv) therapeutic options. Aspergillus, Candida, Cryptococcus, and various mucormycetes species are prevalent in fungal infections, particularly in critically ill patients, such as patients with immunodeficiency diseases. Other rare fungi are also reported. Most pathogenic strains of Candida and Aspergillus are ubiquitous, but others have restricted geographical distribution.

Fungal infections usually originate from primary sites (e.g., fungal pneumonia) or occur after inoculation (e.g., invasive procedures). Substantial progress has been made with new diagnostic approaches and the introduction of novel antifungal drugs. However, in certain cases, invasive fungal infections are frequently lethal due to delayed diagnostics, resistance to antifungal treatments, and inadequate restoration of immune function.

The aim of this Research Topic is to focus on the global fungal epidemiology and problems of diagnosis, treatment, and resistance. We encourage research projects which encompass all strategies aimed at improving treatment practices to achieve optimal outcomes. In addition, we aim to bring together cutting-edge research that will improve diagnostic methods (e.g., molecular detection or targeted genetic analysis for fungus identification), develop new antifungal agents with enhanced tissue penetration efficacy, and further investigate the role of interleukins and host defense mechanisms.

This Research Topic will cover a wide range of subjects including invasive fungal infections, Aspergillus and Candida, multi-drug resistance, susceptibility and antifungal agents, molecular diagnosis and epidemiology etc. This article collection welcomes original research, perspectives, and review articles that meet the general criteria of significance and scientific excellence. Brief Research Reports present original research which may include preliminary/negative findings or report on the non-reproducibility of previously published results. They are intended to present a study in full, but with less detail than in Original Research articles.

Topics of interest include, but are not limited to:

• Fungal infections in immunocompromised patients
• Candidemia
• Cryptococcosis
• Uncommon yeast infections
• Rare fungal infections
• Molecular diagnosis
• Treatment strategy
• Mucormycosis
• Aspergillosis
• Molecular epidemiology
• Interleukins and immune response to fungal infections
• Antifungal susceptibility and resistance


Keywords: Fungal Infections, Candida, Rare Fungal Infections, Filamentous Fungi, Antifungal Drug Resistance


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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