Research Topic

Biology of Gonadotropin-Releasing Hormone Neurons

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The gonadotropin-releasing hormone (GnRH) system is essential for reproduction, with GnRH-expressing neurons dispersed in the forebrain and sending connections to the median eminence of the hypothalamus. In turn, GnRH neurons integrate afferent signals to serve as the final common pathway for central ...

The gonadotropin-releasing hormone (GnRH) system is essential for reproduction, with GnRH-expressing neurons dispersed in the forebrain and sending connections to the median eminence of the hypothalamus. In turn, GnRH neurons integrate afferent signals to serve as the final common pathway for central regulation of reproduction. Disruption of the formation of this circuit leads to delayed or absent puberty and reproductive failure. The GnRH system is well conserved among vertebrates and a homologous system regulating reproduction has recently been described in invertebrates. Given the evolutionary importance of the GnRH system, this Research Topic aims to collect original research and review articles examining the development, maturation, and aging of the GnRH neural circuit, electrophysiological properties of GnRH neurons, and regulatory factors of the GnRH system. Particularly welcome are contributions relating to the differentiation and migration of GnRH neurons, their axonal and dendritic development, and the formation of their afferent inputs.


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