Epilepsy surgery is widely accepted for refractory epilepsies, for which the identification of the epileptogenic zone and its boundary is very important. This multidisciplinary Research Topic will mainly focus on the latest advances in this field. We would like to organize this Topic in three parts.

Firstly, we are interested in the anatomical and functional correlations of the brain. In the past decades, lot of researches aimed to reveal the anatomical and functional correlations of the brain, like it is the case for Brodmann’s area. Topical diagnosis is the fundamental of neurological diagnosis method and with the advance of brain imaging methods, we are able to identify neural structures in detail. With technologies such as Magnetic Resonance Imaging (MRI) and brain tracers techniques, it is possible to reveal brain activity and its potential pathways. With the help of newly developed receptor-based parcellation techniques, we have more precise cytoarchitectonic map of the brain. All this information will help us to correlate epileptogenic zone with anatomic location and ultimately, will contribute to a better understanding of epilepsy and epileptogenic zone location.

Secondly, we would like to cover the methodology for intracranial electroencephalography (iEEG) analysis. With the widely applications of iEEG, which is the gold standard for the definition of epileptogenic zone, several research groups has made the attempt to quantitatively evaluate iEEG data. Despite this preliminary attempt for computer based iEEG analysis, however, there is still no consensus on the method. We would like to analysis the pros and cons of different methodologies and provide some suggestions to this.

Finally, the applications of different techniques for precision neurosurgery in the field of epilepsy surgery is to be addressed. With the help of multidisciplinary cooperation, more and more new surgical instruments are available now. We are now able to achieve the maximum resection of epileptogenic zone with minimal loss. How to make full use of these different methods, such as multimodal imaging, intraoperative monitoring and awake surgery? Are there some surgical tricks? This would also be included in this part.

This Research Topic aims to assemble the latest advances of brain function researches, intracranial EEG analysis methods and surgical tricks in this domain for epilepsy surgeries. We welcome studies using any methods for the interpretation of the functions of the brain and the identification of the epileptogenic zone. We would particularly encourage submission pertaining to under-standing the semiology of epilepsy or improving surgical effects, as well as relevant methodological advances in presurgical evaluations or analysis. Reviews addressing recent advances are also welcome.

Keywords: Refractory epilepsy, Surgery, Anatomy, Function, iEEG analysis

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