Research Topic

Posterior Reversible Encephalopathy Syndrome and Associated Diseases

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About this Research Topic

Posterior reversible encephalopathy syndrome (PRES) has been increasingly recognized due to improved and more readily available diagnostic imaging modalities. Its exact pathophysiology is still not completely understood and remains controversial. Precise diagnosis is essential to guide prompt and proper ...

Posterior reversible encephalopathy syndrome (PRES) has been increasingly recognized due to improved and more readily available diagnostic imaging modalities. Its exact pathophysiology is still not completely understood and remains controversial. Precise diagnosis is essential to guide prompt and proper management. Our ability to differentiate this entity from other acute neurological disorders improves as the full spectrum of this entity continues to be revealed and understood. Recognizing the diagnostic criteria, complications, and biomarkers of PRES and associated diseases will be of great relevance for both evaluation of prognosis and further investigation.

The ability to quickly diagnosis PRES and identify the underlying condition is of paramount significance, as removal or treatment of the underlying condition is necessary to improve patient’s outcome and minimize complications. Although, no specific prognostic biomarker has been precisely identified, several comorbidities and complications have been preliminarily identified as potential biomarkers of outcome. The roles of imaging findings, clinical symptoms and biochemical parameters in predicting prognosis of PRES certainly warrant further investigation. A unified diagnostic algorithm should be sought to standardize the diagnosis of PRES and description of clinical outcome, which will facilitate future research in exploring the role of neuroimaging in this disorder.

In this Research Topic, we welcome some of the world’s leading experts of PRES and associated diseases to produce a series of state-of-the-art reviews and groundbreaking research dealing with it.


Keywords: PRES, MRI, Neuroimaging, Diagnosis, Prognosis, Comorbidity


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