About this Research Topic
The overall picture on the interplay between innate immunity and bone remains highly complex and poorly understood. Advanced biofunctional systems combining diverse cell types and ad-hoc designed biomaterials are currently exploited in in vitro and in vivo studies to dig into this complexity by unravelling the cellular mechanisms, signaling pathways, metabolic factors and other molecular mediators, that tune cell fate and regulate immune responses, with the view of eventually developing innovative strategies for regenerative medicine applications.
In this Research Topic, we aim to focus on osteoimmunology from the perspective of the crosstalk between innate immune cells and bone cells. Namely, we will address: (i) recent advances in the elucidation of the roles of innate immunity in bone homeostasis and repair; (ii) emerging immunological functions of bone cells; (iii) current and emerging biotechnological approaches to dissect osteo-immunological interactions in a physiologically relevant engineered microenvironment and (iv) translational studies built upon this knowledge.
In this framework, we invite contributions of Reviews, Mini-Reviews, Original Research, Opinion and Perspective Articles reporting recent efforts in the field.
We acknowledge the initiation and support of this Research Topic by the International Union of Immunological Societies (IUIS). We hereby state publicly that the IUIS has had no editorial input in articles included in this Research Topic, thus ensuring that all aspects of this Research Topic are evaluated objectively, unbiased by any specific policy or opinion of the IUIS.
Part of the APCs for articles in this collection were financed by the Fondazione Beppe e Nuccy Angiolini ONLUS
Keywords: Society affiliation RT
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