Research Topic

Spatial Genome Organization

About this Research Topic

The organization of genetic loci relative to each other and to nuclear landmarks is non-random. Moreover, this organization is dynamic as it responds to various environmental and signaling cues and is critical to gene expression, genome stability, and stress responses. This dynamic organization of the genome in nuclear space has also provided unique insights and opportunities related to development, health, and disease of organisms.

This Research Topic will aim to capture exciting and recent developments in our understanding of three-dimensional genome organization in various organisms, tissues, and cell states.

All articles related to spatial genome organization will be considered for this Research Topic, which may include submissions from the following areas: structure and function of sub-nuclear domains; topologically associated domains or similar domains; signalling cues; cellular states; DNA damage and repair; genome structure in health and disease; genome editing; super-resolution microscopy; chromosome conformation capture, sequencing and databases.

Details for authors: The topic will include various Frontiers article types including Original Research and Review papers.


Keywords: Nuclear organization, Cell biology, Chromosome conformation, Gene expression, Genome stability


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

The organization of genetic loci relative to each other and to nuclear landmarks is non-random. Moreover, this organization is dynamic as it responds to various environmental and signaling cues and is critical to gene expression, genome stability, and stress responses. This dynamic organization of the genome in nuclear space has also provided unique insights and opportunities related to development, health, and disease of organisms.

This Research Topic will aim to capture exciting and recent developments in our understanding of three-dimensional genome organization in various organisms, tissues, and cell states.

All articles related to spatial genome organization will be considered for this Research Topic, which may include submissions from the following areas: structure and function of sub-nuclear domains; topologically associated domains or similar domains; signalling cues; cellular states; DNA damage and repair; genome structure in health and disease; genome editing; super-resolution microscopy; chromosome conformation capture, sequencing and databases.

Details for authors: The topic will include various Frontiers article types including Original Research and Review papers.


Keywords: Nuclear organization, Cell biology, Chromosome conformation, Gene expression, Genome stability


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

07 June 2019 Abstract
09 August 2019 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

07 June 2019 Abstract
09 August 2019 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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