Cardiovascular diseases (CVDs), the first cause of death globally, with 17.9 million deaths estimated each year, are gaining in prevalence worldwide. CVDs include conditions that affect the structure and function of heart and blood vessels, such coronary heart disease, peripheral arterial disease, aortic disease, cerebrovascular disease, rheumatic heart disease and other conditions. Evidence from experimental and clinical studies have shown that oxidative stress, inflammation and autophagy are closely associated with CVDs, being also reciprocally induced. Indeed, anti-inflammatory therapies have demonstrated protective effects both in models of cardiovascular disease and in large-scale clinical trials which revealed reduced cardiovascular mortality in patients with CVDs. However, the relationship between increased oxidative stress, inflammation, and autophagy deregulation in CVDs, and the molecular mechanisms underlying these alterations are not completely clarified.
We invite investigators to contribute original research articles, as well as review articles focusing on the emerging role of oxidative stress and inflammation in CVDs.
We hope that the articles published in this Research Topic will contribute to the understanding of the pathogenetic mechanisms of cardiovascular diseases, and will permit the discovery of novel specific biomarkers and the setting up of new potential therapeutic approaches for the treatment of CVDs.
Areas to be covered in this Research Topic may include, but are not limited to:
• Targeting new pathways involved in CVDs pathogenesis for diagnostic and therapeutic purposes;
• New oxidative stress biomarkers in CVDs;
• Research focused on “-omics”-based technologies used for personalized medicine;
• Pharmacological agents that modulate redox regulation in CVDs;
•
In vitro and
in vivo studies on the role of autophagy in CVDs;
• The interplay between autophagy dis-regulation and oxidative stress damage in CVDs;
• Pharmacological and non-pharmacological approaches to modulate autophagy and ROS production including dietary interventions;
• Characterization of signalling pathways.
A list of accepted article types including descriptions can be found at this
link.
