Redox homeostasis is an important component for the maintenance of a normal physiological steady state in the human body. Redox homeostasis is achieved by the controlled regulation of both reactive oxygen species formation and their removal from the body system. A deviation from the homeostasis results in redox imbalance which, in turn, leads to oxidative stress that causes irreversible cellular damage and various pathological conditions. Natural products are the backbone, not only for traditional medicinal systems, but also for modern medicine, as many modern drugs are derived from natural sources. Natural compounds that regulate redox imbalance can be used in the treatment and prevention of various degenerative diseases.
Redox imbalance triggers oxidative insult by inflicting damage to biomolecules and inducing cellular inconsistencies, which ultimately can contribute to disease development. Oxidative stress in various cellular organelles, such as endoplasmic reticulum and mitochondria, exhibits a direct link between redox imbalance, metabolism, and genetic control machinery in the body. Natural products, having diverse structures, possess the ability to modulate the cellular redox equilibrium at the biochemical and molecular levels. Natural product-derived remedy/drugs are known for several advantages over synthetic drugs which include cost-effectiveness, lesser or no side effects, and better availability for a given population. Numerous natural products are known for their role in the management of redox imbalance, but their efficacy in associated pathological conditions still needs to be studied. Furthermore, there is the possibility of exploring new drug lead compounds of natural origin to combat oxidative stress. Hence, targeting redox imbalance associated complications by natural products could be a better strategy for the management of various diseases.
The goal of the present Research Topic encompasses the identification of new pharmacological targets and the introduction of novel therapies for the treatment of redox imbalance associated disease/disorders in the context of natural product research.
The management of redox imbalance complications by natural products is scientifically, medically, and economically highly relevant. Our Research Topic aims to gather up-to-date knowledge related to cutting-edge research in the scientific area of the pharmacology of natural products and their applications. We are seeking manuscripts of outstanding interest covering the breadth of public health and pharmaceutical applications of natural products accompanying mechanistic insights associated with the interaction of natural compounds/plant extracts and living systems.
Manuscripts merely based on chemical antioxidant assays, like the DPPH assay, will not be accepted since these studies lack pharmacological relevance and information regarding the therapeutic efficacy of the test product. Only manuscripts describing pharmacological activities of natural compounds using various in vitro and in vivo models are desirable. However, these activities should be specific and not linked to general food effects.
Under this Research Topic, the effect of natural compounds on the following complications/disorders related to redox imbalance will be covered, but are not limited to:
• Diabetes
• Hepatic and gastrointestinal anomalies
• Cardiovascular disease
• Neurodegenerative disease
• Cancer
• Aging
• Inflammatory disease
• Immune response related to redox imbalance
All manuscripts submitted to this Research Topic will need to fully comply with the Four Pillars of Best Practice in Ethnopharmacology (http://www.frontiersin.org/files/pdf/4_pillars_FULL_TEXT.pdf).
Redox homeostasis is an important component for the maintenance of a normal physiological steady state in the human body. Redox homeostasis is achieved by the controlled regulation of both reactive oxygen species formation and their removal from the body system. A deviation from the homeostasis results in redox imbalance which, in turn, leads to oxidative stress that causes irreversible cellular damage and various pathological conditions. Natural products are the backbone, not only for traditional medicinal systems, but also for modern medicine, as many modern drugs are derived from natural sources. Natural compounds that regulate redox imbalance can be used in the treatment and prevention of various degenerative diseases.
Redox imbalance triggers oxidative insult by inflicting damage to biomolecules and inducing cellular inconsistencies, which ultimately can contribute to disease development. Oxidative stress in various cellular organelles, such as endoplasmic reticulum and mitochondria, exhibits a direct link between redox imbalance, metabolism, and genetic control machinery in the body. Natural products, having diverse structures, possess the ability to modulate the cellular redox equilibrium at the biochemical and molecular levels. Natural product-derived remedy/drugs are known for several advantages over synthetic drugs which include cost-effectiveness, lesser or no side effects, and better availability for a given population. Numerous natural products are known for their role in the management of redox imbalance, but their efficacy in associated pathological conditions still needs to be studied. Furthermore, there is the possibility of exploring new drug lead compounds of natural origin to combat oxidative stress. Hence, targeting redox imbalance associated complications by natural products could be a better strategy for the management of various diseases.
The goal of the present Research Topic encompasses the identification of new pharmacological targets and the introduction of novel therapies for the treatment of redox imbalance associated disease/disorders in the context of natural product research.
The management of redox imbalance complications by natural products is scientifically, medically, and economically highly relevant. Our Research Topic aims to gather up-to-date knowledge related to cutting-edge research in the scientific area of the pharmacology of natural products and their applications. We are seeking manuscripts of outstanding interest covering the breadth of public health and pharmaceutical applications of natural products accompanying mechanistic insights associated with the interaction of natural compounds/plant extracts and living systems.
Manuscripts merely based on chemical antioxidant assays, like the DPPH assay, will not be accepted since these studies lack pharmacological relevance and information regarding the therapeutic efficacy of the test product. Only manuscripts describing pharmacological activities of natural compounds using various in vitro and in vivo models are desirable. However, these activities should be specific and not linked to general food effects.
Under this Research Topic, the effect of natural compounds on the following complications/disorders related to redox imbalance will be covered, but are not limited to:
• Diabetes
• Hepatic and gastrointestinal anomalies
• Cardiovascular disease
• Neurodegenerative disease
• Cancer
• Aging
• Inflammatory disease
• Immune response related to redox imbalance
All manuscripts submitted to this Research Topic will need to fully comply with the Four Pillars of Best Practice in Ethnopharmacology (http://www.frontiersin.org/files/pdf/4_pillars_FULL_TEXT.pdf).