Success rates for therapeutics during clinical development remain low due to the lack of appropriate and efficient in vitro and in vivo models allowing for the development of promising drug candidates and understanding the fundamental mechanisms involved in diseases. Three-dimensional (3D) model systems, including spheroids, organoids, and tissue models, are more realistic and reproducible to recapitulate the biological and physiological properties and functions of cultured cells and tissues. Therefore, 3D (together with animal models that are fit-for-purpose) are essential for the translation of preclinical findings from bench to bedside. Most recently, new technologies and refinements of existing technologies in this area have been emerging. Hence, better design, conduct, and further development of these models are warranted to bridge the translational gap between preclinical and clinical research.
In this Research Topic, we invite you to contribute original research articles, reviews, or “Perspective” articles on all aspects related to the theme of “Emerging 3D and Animal Models in Diseases and Therapeutics”. We hope to demystify novel 3D and animal models systems developed in the most recent years, explore the advances and challenges relevant and on-point, and provide practical insight for successfully translating them into clinical applications.
• New techniques of 3D and animal models
• Advances and progress of 3D and animal models
• Review, standardization and refinement of 3D and animal models
• Novel 3D model systems, including but not limited to spheroids, organoids, and tissue models
• Novel animal models in rat, mouse, and zebrafish, including but not limited to CRISPR knockout/knockin models and humanization of models
• Application of 3D and animal models in diseases, including but not limited to cancer, neurodegeneration, vascular disorders.
• Application of 3D and animal models in therapeutics, including drug development, screening, evaluation, and treatment
• The translational value of 3D and animal models
Success rates for therapeutics during clinical development remain low due to the lack of appropriate and efficient in vitro and in vivo models allowing for the development of promising drug candidates and understanding the fundamental mechanisms involved in diseases. Three-dimensional (3D) model systems, including spheroids, organoids, and tissue models, are more realistic and reproducible to recapitulate the biological and physiological properties and functions of cultured cells and tissues. Therefore, 3D (together with animal models that are fit-for-purpose) are essential for the translation of preclinical findings from bench to bedside. Most recently, new technologies and refinements of existing technologies in this area have been emerging. Hence, better design, conduct, and further development of these models are warranted to bridge the translational gap between preclinical and clinical research.
In this Research Topic, we invite you to contribute original research articles, reviews, or “Perspective” articles on all aspects related to the theme of “Emerging 3D and Animal Models in Diseases and Therapeutics”. We hope to demystify novel 3D and animal models systems developed in the most recent years, explore the advances and challenges relevant and on-point, and provide practical insight for successfully translating them into clinical applications.
• New techniques of 3D and animal models
• Advances and progress of 3D and animal models
• Review, standardization and refinement of 3D and animal models
• Novel 3D model systems, including but not limited to spheroids, organoids, and tissue models
• Novel animal models in rat, mouse, and zebrafish, including but not limited to CRISPR knockout/knockin models and humanization of models
• Application of 3D and animal models in diseases, including but not limited to cancer, neurodegeneration, vascular disorders.
• Application of 3D and animal models in therapeutics, including drug development, screening, evaluation, and treatment
• The translational value of 3D and animal models
