Immune Modulation in Tumor Microenvironment: New Perspectives for Cancer Immunotherapy

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Editorial

04 January 2023

Editorial: Immune modulation in tumor microenvironment: New perspectives for cancer immunotherapy

Zimu Deng

,

Xuejun Sun

,

Jian Cao

and

Qian Xiao

1,536 views

3 citations

Editors

4

Qian Xiao

Rutgers Cancer Institute of New Jersey, Rutgers, The State University of New Jersey

Xuejun Sun

Xi'an Jiaotong University

Zimu Deng

Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences (CAS)

Jian Cao

Rutgers Cancer Institute of New Jersey, Rutgers, The State University of New Jersey

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Emerging immunotherapies, such as the immune checkpoint blockade therapy (ICB) and chimeric antigen receptors T-cell (CAR-T) therapy, have achieved promising results in treating certain types of cancer. However, not all cancer patients benefit from these advanced immunotherapeutic approaches because of intrinsic and acquired resistance. Tumors are heterogeneous and structurally complex tissues comprised of various types of cells, including tumor cells, fibroblasts, immune cells, endothelial cells, and extracellular structural and signaling molecules. Together they form tumor microenvironment (TME), in which various mechanisms are initiated by tumor cells, non-tumor cells, extracellular matrix proteins, signal factors, and metabolic molecules to suppress anti-tumor immune response. Intensive investigations have focused on discovering these mechanisms, developing strategies to overcome immunosuppressive TME, and improving the efficiency of immunotherapies.

This Research Topic focuses on the immunosuppressive TME in tumor initiation, progression, and resistance to immunotherapies. We aim to publish a collection of outstanding studies on (1) TME-based immune escape mechanisms; (2) key immune modulators in TME and their regulated signaling/pathways; and (3) strategies and approaches to alter immunosuppressive TME in favor of response to immunotherapies.

We welcome contributions in the form of Original Research Articles, Reviews, and Mini-Reviews that cover but are not limited to the following topics related to immune modulators in TME:

- Modulation of immune TME by tumor-intrinsic signals

- Immunoregulatory cells in TME and their immunostimulatory and immunosuppressive mechanisms

- Chronic infection, inflammation, and cancer progression

- Extracellular factors secreted by tumor and non-tumor cells that regulate the activation and exhaustion of tumor-infiltrating immune cells

- Chemokine/cytokines-introduced immunosuppression in TME

- Landscape of immune TME via data integration and bioinformatic analysis

- Strategies of targeting immune modulator/immune cell for cancer therapies

Methods describing new technological approaches to study immune modulation in tumor microenvironment are also welcome.

Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserve the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Emerging immunotherapies, such as the immune checkpoint blockade therapy (ICB) and chimeric antigen receptors T-cell (CAR-T) therapy, have achieved promising results in treating certain types of cancer. However, not all cancer patients benefit from these advanced immunotherapeutic approaches because of intrinsic and acquired resistance. Tumors are heterogeneous and structurally complex tissues comprised of various types of cells, including tumor cells, fibroblasts, immune cells, endothelial cells, and extracellular structural and signaling molecules. Together they form tumor microenvironment (TME), in which various mechanisms are initiated by tumor cells, non-tumor cells, extracellular matrix proteins, signal factors, and metabolic molecules to suppress anti-tumor immune response. Intensive investigations have focused on discovering these mechanisms, developing strategies to overcome immunosuppressive TME, and improving the efficiency of immunotherapies.

This Research Topic focuses on the immunosuppressive TME in tumor initiation, progression, and resistance to immunotherapies. We aim to publish a collection of outstanding studies on (1) TME-based immune escape mechanisms; (2) key immune modulators in TME and their regulated signaling/pathways; and (3) strategies and approaches to alter immunosuppressive TME in favor of response to immunotherapies.

We welcome contributions in the form of Original Research Articles, Reviews, and Mini-Reviews that cover but are not limited to the following topics related to immune modulators in TME:

- Modulation of immune TME by tumor-intrinsic signals

- Immunoregulatory cells in TME and their immunostimulatory and immunosuppressive mechanisms

- Chronic infection, inflammation, and cancer progression

- Extracellular factors secreted by tumor and non-tumor cells that regulate the activation and exhaustion of tumor-infiltrating immune cells

- Chemokine/cytokines-introduced immunosuppression in TME

- Landscape of immune TME via data integration and bioinformatic analysis

- Strategies of targeting immune modulator/immune cell for cancer therapies

Methods describing new technological approaches to study immune modulation in tumor microenvironment are also welcome.

Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserve the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Editors

Qian Xiao

Rutgers Cancer Institute of New Jersey, Rutgers, The State University of New Jersey

Xuejun Sun

Xi'an Jiaotong University

Zimu Deng

Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences (CAS)

Jian Cao

Rutgers Cancer Institute of New Jersey, Rutgers, The State University of New Jersey

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103,713 Total views

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Published In

Frontiers in Cell and Developmental Biology

Molecular and Cellular Pathology

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