Free radicals are one main causative agent triggering accelerated aging, and this offers some opportunities for preventive pharmacological. Skin aging mainly results from the disturbance in the equilibrium between the regenerative and degenerative metabolism of the skin, triggering wrinkling as well as a thinning of the epidermis. These dermal variations are extensively accompanied by loss and deterioration in collagen, elastin fibers with decreased circulatory perfusion. A large array of anti-aging products are obtained from naturally occurring origin that effectively maintain the distorted equilibrium between the regenerative/ degenerative potential of the skin and concomitantly restore the generation of elastin and collagen, as studied with ginseng. Other plant products result in transient moisturizing effects.
We then also have the theory of oxidative stress in aging, which is based on the hypothesis that age-accompanied functional disruptions are mainly attributed to the accumulation of reactive oxygen and nitrogen species (RONS)-induced damages ultimately leading to oxidative stress.
Since drugs from natural sources including plants, fungi and marine organisms as well as their associated micro-organisms display a wide array of medicinal values, in this research topic we explore the potential role of complex mixtures and pure natural product to counteract the aging process including potential effects on oxidative stress.
Within this theme we encourage high quality, mechanistic – in vitro pharmacological, clinical studies and studies focusing on the formulation and delivery of the finished products, as well as approaches to further develop the methods to assess for potential anti-aging effects. Short communications, research articles as well as review articles are welcome.
Potential topics include:
• Isolation and identification of bioactive metabolites from natural sources as potential treatments of accelerated aging including oxidative stress
• Metabolic profiling of secondary metabolites in plants /or marine extracts that displayed a pronounced anti-aging potential including antioxidant effects
• Mechanistic assessments of the anti-aging effects of natural product
• The potential of essential oils counteracting accelerated aging and oxidative stress
• Formulations based natural products with an effect on the aging process (not nanotechnological formulations are normally not accepted).
The characterization of the major constituents via LC/MS profiling or isolation / structural elucidation is a fundamental requirement of all manuscripts.
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All the manuscripts submitted to the collection will need to fully comply with the
Four Pillars of Best Practice in Ethnopharmacology (you can freely download the full version
here).