The role of nanomedicines, particularly in the perspective of precision therapy development and drug delivery, is escalating worldwide in various healthcare fields especially given the global pandemic. The nano-interventions have been of utmost importance for designing effective therapeutic and prophylactic strategies to combat COVID-19. Before COVID, nanomaterials had already established their potential as vehicles for different pharmaceuticals against various infections and diseases. While small molecule and macromolecular-based therapies are key in treating various diseases, their traditional approaches have mostly failed due to their poor efficiency at identifying and reaching specific targets. Compared to the traditional approaches, nanomedicines possess the potential of addressing the above challenges. However, due to the method complexities in the perspective of target specificity, safety, stability and upscaling, the development of nanomedicines is challenging. Recent advances in biomedics, chemometrics, and genome engineering tools have been shown to increase the therapeutic profile of various drugs while enhancing the encapsulation efficiency, shelf and half-life, and controlled release features, thus minimizing the side effects.
In this Research Topic, we invite submissions that describe recent advances in the development of chemical and material tools to enhance the therapeutic index of drugs for different diseases. In this special call, we intend to highlight the importance of chemical and material tools, ranging from their preparation to their utilization in the delivery of pharmaceuticals. This Research Topic will also showcase the diversity of research being performed in pharmaceuticals globally, including solutions to the challenges encountered in the preparation, optimization, simulation, evaluation and effective distribution of pharmaceuticals. According to the general rules of this section, manuscripts including in silico only data as well as manuscripts with non-purified natural substances and/or mixtures will not considered.
The role of nanomedicines, particularly in the perspective of precision therapy development and drug delivery, is escalating worldwide in various healthcare fields especially given the global pandemic. The nano-interventions have been of utmost importance for designing effective therapeutic and prophylactic strategies to combat COVID-19. Before COVID, nanomaterials had already established their potential as vehicles for different pharmaceuticals against various infections and diseases. While small molecule and macromolecular-based therapies are key in treating various diseases, their traditional approaches have mostly failed due to their poor efficiency at identifying and reaching specific targets. Compared to the traditional approaches, nanomedicines possess the potential of addressing the above challenges. However, due to the method complexities in the perspective of target specificity, safety, stability and upscaling, the development of nanomedicines is challenging. Recent advances in biomedics, chemometrics, and genome engineering tools have been shown to increase the therapeutic profile of various drugs while enhancing the encapsulation efficiency, shelf and half-life, and controlled release features, thus minimizing the side effects.
In this Research Topic, we invite submissions that describe recent advances in the development of chemical and material tools to enhance the therapeutic index of drugs for different diseases. In this special call, we intend to highlight the importance of chemical and material tools, ranging from their preparation to their utilization in the delivery of pharmaceuticals. This Research Topic will also showcase the diversity of research being performed in pharmaceuticals globally, including solutions to the challenges encountered in the preparation, optimization, simulation, evaluation and effective distribution of pharmaceuticals. According to the general rules of this section, manuscripts including in silico only data as well as manuscripts with non-purified natural substances and/or mixtures will not considered.