Calcium and bone metabolism is tightly regulated by a number of humoral factors, such as 1,25-dihydroxyvitamin D3, parathyroid hormone, calcitonin, growth hormone and insulin, among others. Besides these classical calcium-regulating hormones, for example: intestinal epithelial cells, liver, muscle, megakaryocytes, and hematopoietic cells, are able to secrete endocrine and/or paracrine factors to fine-tune intestinal calcium absorption, bone remodeling, renal calcium excretion and plasma calcium levels. Moreover, bone turnover is also modulated by neural signals, circulating metabolites and molecules produced by gut microbiota. Therefore, the present Research Topic focuses on the crosstalk and cell-cell communications that affect calcium and bone metabolism.
The present Research Topic aims to elaborate cutting-edge findings that explain how other cells, tissues and organs modulate the functions of bone and major calcium-handling organs (such as the intestines and kidneys). In addition to the three classical hormones, namely parathyroid hormone, vitamin D and calcitonin, there are a number of humoral and neural factors that are capable of modulating calcium and bone metabolism; however, many findings are controversial or inconclusive. For example, myokines released from the skeletal muscle during exercise are believed to enhance bone formation and prevent osteoporosis, but whether myokines predominantly contribute to the bone-forming processes remains unclear. In the close vicinity of bone cells, other cells (including adipocytes, megakaryocytes, macrophages, etc.) are able to release cytokines to control bone turnover, although their physiological significances remain to be elucidated. Thus, this Research Topic should extend the frontiers of calcium and bone physiology.
Original research articles, mini-reviews and comprehensive review articles are welcome. The contents may cover any aspects of calcium and bone physiology, including, but not limited to:
- How other cells and tissues modulate bone turnover through endocrine, paracrine or neurocrine mediators
- How neighboring cells in bone marrow interact with bone cells
- How circulating metabolites (e.g., sugars, lipids, peptides)
- How the products of gut microbiota affect bone turnover
- Osteokines and myokines
- Gut-drived hormones and bone
- Bone marrow cytokines
- Microbiome-derived circulating factors
- Direct cell-cell communication between bone cells
Calcium and bone metabolism is tightly regulated by a number of humoral factors, such as 1,25-dihydroxyvitamin D3, parathyroid hormone, calcitonin, growth hormone and insulin, among others. Besides these classical calcium-regulating hormones, for example: intestinal epithelial cells, liver, muscle, megakaryocytes, and hematopoietic cells, are able to secrete endocrine and/or paracrine factors to fine-tune intestinal calcium absorption, bone remodeling, renal calcium excretion and plasma calcium levels. Moreover, bone turnover is also modulated by neural signals, circulating metabolites and molecules produced by gut microbiota. Therefore, the present Research Topic focuses on the crosstalk and cell-cell communications that affect calcium and bone metabolism.
The present Research Topic aims to elaborate cutting-edge findings that explain how other cells, tissues and organs modulate the functions of bone and major calcium-handling organs (such as the intestines and kidneys). In addition to the three classical hormones, namely parathyroid hormone, vitamin D and calcitonin, there are a number of humoral and neural factors that are capable of modulating calcium and bone metabolism; however, many findings are controversial or inconclusive. For example, myokines released from the skeletal muscle during exercise are believed to enhance bone formation and prevent osteoporosis, but whether myokines predominantly contribute to the bone-forming processes remains unclear. In the close vicinity of bone cells, other cells (including adipocytes, megakaryocytes, macrophages, etc.) are able to release cytokines to control bone turnover, although their physiological significances remain to be elucidated. Thus, this Research Topic should extend the frontiers of calcium and bone physiology.
Original research articles, mini-reviews and comprehensive review articles are welcome. The contents may cover any aspects of calcium and bone physiology, including, but not limited to:
- How other cells and tissues modulate bone turnover through endocrine, paracrine or neurocrine mediators
- How neighboring cells in bone marrow interact with bone cells
- How circulating metabolites (e.g., sugars, lipids, peptides)
- How the products of gut microbiota affect bone turnover
- Osteokines and myokines
- Gut-drived hormones and bone
- Bone marrow cytokines
- Microbiome-derived circulating factors
- Direct cell-cell communication between bone cells
