Aging is associated with dysregulated metabolism. Recently, cellular metabolism in immune cells has been emphasized as a significant modifier of immune cell function. Metabolic control of the immune system provides information about cellular mechanisms that affect immune cell fate and function. Cell intrinsic and extrinsic signals modulate the activity of immune cells by altering metabolism. Metabolic signaling helps regulate the growth, proliferation, and survival needs of immune cells while also influencing effector function. Furthermore, metabolism functions are a highly complex network for both cell signaling and cell-cell and cell-environment interactions. Improving our understanding of immune cell metabolism at the signaling, cellular, and systems levels will provide new opportunities for therapeutic targeting of aging-related diseases.
The goal of this Research Topic is to understand the connections of immune metabolic programs, including glycolysis, mitochondrial metabolism, lipids, and ER homeostasis with aging-related diseases. We aim to address the latest developments in this field including but not limited to:
• Understanding of metabolic controls of immune cells biology;
• The functional impacts of immune metabolic mechanisms on age-related diseases.
• The role of metabolic signaling on immune cells' state and fate
• Effect of immune cell-specific glycolysis on age-related diseases
• Immune cell mitochondrial metabolism
• Links between immune cell-specific Lipid metabolism and age-related diseases
• Links between immune cell ER homeostasis and age-related diseases
• Metabolic changes and requirements underlying immune cells development and activation
• Roles of metabolites in both innate and adaptive immune systems
• Sensing and signaling mechanisms underlying how nutrients license immune cell function
Please Note: Descriptive studies (e.g. gene expression profiles, or transcript, protein, or metabolite levels under particular conditions or in a particular cell type) and studies consisting solely of bioinformatic investigation of publicly available genomic / transcriptomic data do not fall within the scope of the journal unless they are expanded and provide significant biological or mechanistic insight into the process being studied.
Aging is associated with dysregulated metabolism. Recently, cellular metabolism in immune cells has been emphasized as a significant modifier of immune cell function. Metabolic control of the immune system provides information about cellular mechanisms that affect immune cell fate and function. Cell intrinsic and extrinsic signals modulate the activity of immune cells by altering metabolism. Metabolic signaling helps regulate the growth, proliferation, and survival needs of immune cells while also influencing effector function. Furthermore, metabolism functions are a highly complex network for both cell signaling and cell-cell and cell-environment interactions. Improving our understanding of immune cell metabolism at the signaling, cellular, and systems levels will provide new opportunities for therapeutic targeting of aging-related diseases.
The goal of this Research Topic is to understand the connections of immune metabolic programs, including glycolysis, mitochondrial metabolism, lipids, and ER homeostasis with aging-related diseases. We aim to address the latest developments in this field including but not limited to:
• Understanding of metabolic controls of immune cells biology;
• The functional impacts of immune metabolic mechanisms on age-related diseases.
• The role of metabolic signaling on immune cells' state and fate
• Effect of immune cell-specific glycolysis on age-related diseases
• Immune cell mitochondrial metabolism
• Links between immune cell-specific Lipid metabolism and age-related diseases
• Links between immune cell ER homeostasis and age-related diseases
• Metabolic changes and requirements underlying immune cells development and activation
• Roles of metabolites in both innate and adaptive immune systems
• Sensing and signaling mechanisms underlying how nutrients license immune cell function
Please Note: Descriptive studies (e.g. gene expression profiles, or transcript, protein, or metabolite levels under particular conditions or in a particular cell type) and studies consisting solely of bioinformatic investigation of publicly available genomic / transcriptomic data do not fall within the scope of the journal unless they are expanded and provide significant biological or mechanistic insight into the process being studied.
