Red blood cells (RBCs), or erythrocytes, are unique, highly specialized and the most abundant cells in different organisms. Although their primary function is the transportation of the respiratory gases, O2 and CO2, between lungs and tissues, these circulatory cells are equipped with effective anti-oxidative systems that make them mobile free radical scavengers, providing antioxidant protection not only to themselves but also to other tissues and organs in the body. While a certain amount of oxidative stress is useful to the body for growth and cell signaling, excess levels, produced by several endogenous and exogenous processes, have deleterious effects on cell components including proteins lipids and alter the redox status of the cell. RBCs are highly susceptible to oxidative damage due to the high cell concentration of oxygen and hemoglobin, powerful promoters of the oxidative process. In fact, they are one of the first cells to be affected by adverse conditions. During oxidative stress, human erythrocytes can undergo biochemical changes, e.g. disruption in the molecular arrangement of the bilayer as well as biophysical alterations, e.g. changes in the general structural arrangement, morphology and mechanics.
The aim of this Research Topic is to provide more information about the cell response to oxidative stress in pathologic conditions, mainly in those displaying systemic oxidative stress as hallmark. This Research Topic will focus on the investigation of the molecular mechanisms underlying the effects of oxidative stress on red blood cells and their cellular components, including membrane ion transport systems, and the cell redox endogenous system. To this aim, the beneficial effects of antioxidants and possible mechanisms of cell adaptation in the context of imbalance in oxidative-related diseases will be worthy of note. In vivo studies and studies using human or animal cells are welcome
This Research Topic welcomes manuscripts contributing to the dissemination of high-quality research articles, as well as review articles, focusing on the relationship between oxidative stress and cellular responses in chronic diseases. Potential topics include but are not limited to the following:
• Alterations in RBCs membrane transport in response to oxidative stress.
• Biophysical and biochemical changes in RBCs properties in response to oxidative stress.
• The use of red blood cells as drug carriers or biomarkers of oxidative stress.
• The response of RBCs to oxidative stress in aging.
Red blood cells (RBCs), or erythrocytes, are unique, highly specialized and the most abundant cells in different organisms. Although their primary function is the transportation of the respiratory gases, O2 and CO2, between lungs and tissues, these circulatory cells are equipped with effective anti-oxidative systems that make them mobile free radical scavengers, providing antioxidant protection not only to themselves but also to other tissues and organs in the body. While a certain amount of oxidative stress is useful to the body for growth and cell signaling, excess levels, produced by several endogenous and exogenous processes, have deleterious effects on cell components including proteins lipids and alter the redox status of the cell. RBCs are highly susceptible to oxidative damage due to the high cell concentration of oxygen and hemoglobin, powerful promoters of the oxidative process. In fact, they are one of the first cells to be affected by adverse conditions. During oxidative stress, human erythrocytes can undergo biochemical changes, e.g. disruption in the molecular arrangement of the bilayer as well as biophysical alterations, e.g. changes in the general structural arrangement, morphology and mechanics.
The aim of this Research Topic is to provide more information about the cell response to oxidative stress in pathologic conditions, mainly in those displaying systemic oxidative stress as hallmark. This Research Topic will focus on the investigation of the molecular mechanisms underlying the effects of oxidative stress on red blood cells and their cellular components, including membrane ion transport systems, and the cell redox endogenous system. To this aim, the beneficial effects of antioxidants and possible mechanisms of cell adaptation in the context of imbalance in oxidative-related diseases will be worthy of note. In vivo studies and studies using human or animal cells are welcome
This Research Topic welcomes manuscripts contributing to the dissemination of high-quality research articles, as well as review articles, focusing on the relationship between oxidative stress and cellular responses in chronic diseases. Potential topics include but are not limited to the following:
• Alterations in RBCs membrane transport in response to oxidative stress.
• Biophysical and biochemical changes in RBCs properties in response to oxidative stress.
• The use of red blood cells as drug carriers or biomarkers of oxidative stress.
• The response of RBCs to oxidative stress in aging.
