Programmed cell death is a predefined collective suicide activity of cells in multicellular organisms. It comprises apoptosis, autophagy, ferroptosis, pyroptosis, and other forms of cell death. It is essential for organism evolution, internal stability, and the development of our systems. Aberrant regulation in this process is linked to a variety of illnesses, including immunological diseases and developmental abnormalities, neurological diseases, and cancer, suggesting that programmed cell death plays a significant role in physiology and pathophysiology and could be a potential target for therapies in many conditions.
Oxidative stress (OS) is driven by a condition where our bodies’ oxidative and antioxidation systems are out of balance, causing various human diseases, such as aging, carcinogenesis, and degenerative illnesses. Numerous studies have found that oxidative stress plays a pivotal role in the pathogenesis of human disease by promoting cell death, including apoptosis, necroptosis, pyroptosis, ferroptosis, and oxeiptosis, or by disrupting pro-survival signals like autophagy and unfolded protein response. Therefore, lowering oxidative stress could shed light on the treatment of these diseases by maintaining the balance between cell death and cell survival. However, this field has not been fully understood: the role and the mechanisms of oxidative stress in diseases need to be further revealed, the regulatory pathways involved in this process should be further identified, and the translational potential must be investigated.
This Research Topic aims to collect original research papers as well as review articles that will enhance our understanding of the cellular and molecular pathways during OS and/or distinct cell death. In addition, studies from clinical data with a focus on physiological and pathological mechanisms are also welcomed (especially in dealing with diseases related to oxidative stress, such as aging, cancer, cerebrovascular diseases, Alzheimer's disease, Parkinson's disease, etc.).
We also welcome studies that disclose novel and important targets and processes involved in OS and distinct cell death that might be used for translational research in human illnesses.
• Fundamental research regarding the roles of OS and/or distinct cell death in diseases;
• Discovery of the relationship between OS and cell death;
• Clinical research regarding the treatment or prevention of OS and/or cell death-related diseases;
• Novel strategies based on network pharmacology in preventing OS and cell death;
• Bioinformatic analysis in key regulators of OS and cell death.
Programmed cell death is a predefined collective suicide activity of cells in multicellular organisms. It comprises apoptosis, autophagy, ferroptosis, pyroptosis, and other forms of cell death. It is essential for organism evolution, internal stability, and the development of our systems. Aberrant regulation in this process is linked to a variety of illnesses, including immunological diseases and developmental abnormalities, neurological diseases, and cancer, suggesting that programmed cell death plays a significant role in physiology and pathophysiology and could be a potential target for therapies in many conditions.
Oxidative stress (OS) is driven by a condition where our bodies’ oxidative and antioxidation systems are out of balance, causing various human diseases, such as aging, carcinogenesis, and degenerative illnesses. Numerous studies have found that oxidative stress plays a pivotal role in the pathogenesis of human disease by promoting cell death, including apoptosis, necroptosis, pyroptosis, ferroptosis, and oxeiptosis, or by disrupting pro-survival signals like autophagy and unfolded protein response. Therefore, lowering oxidative stress could shed light on the treatment of these diseases by maintaining the balance between cell death and cell survival. However, this field has not been fully understood: the role and the mechanisms of oxidative stress in diseases need to be further revealed, the regulatory pathways involved in this process should be further identified, and the translational potential must be investigated.
This Research Topic aims to collect original research papers as well as review articles that will enhance our understanding of the cellular and molecular pathways during OS and/or distinct cell death. In addition, studies from clinical data with a focus on physiological and pathological mechanisms are also welcomed (especially in dealing with diseases related to oxidative stress, such as aging, cancer, cerebrovascular diseases, Alzheimer's disease, Parkinson's disease, etc.).
We also welcome studies that disclose novel and important targets and processes involved in OS and distinct cell death that might be used for translational research in human illnesses.
• Fundamental research regarding the roles of OS and/or distinct cell death in diseases;
• Discovery of the relationship between OS and cell death;
• Clinical research regarding the treatment or prevention of OS and/or cell death-related diseases;
• Novel strategies based on network pharmacology in preventing OS and cell death;
• Bioinformatic analysis in key regulators of OS and cell death.
