Posttranslational modification (PTM) refers to the covalent chemical modifications of proteins after protein
biosynthesis. PTM mainly consists of methylation, phosphorylation, acetylation, ubiquitylation, SUMOylation,
glycosylation, and ADP-ribosylation. PTM is crucial to the structure and function of the protein, and nearly
affects all aspects of cell biology and pathogenesis. Identification and characterization of PTM to specific
modifications on proteins are essential to discern the functional significance in biological contexts. On the
other hand, innate and adaptive immune responses play a critical role in the development of human diseases.
Immunotherapy has emerged as an attractive approach to treating complex diseases by activating the immune
system.
In recent years, many findings have shown that PTMs are closely associated with immune regulation by
affecting immune cellular function and metabolic reprogramming. For instance, PTMs could promote PD-L1
mediated tumor immune escape by disrupting the protein stability to block the binding of PD-1 and PD-L1,
thus promoting autoimmune responses. Given that PTM of immune factors is closely related to the
pathogenesis and development of diseases such as cancer, cardiovascular, neurodegenerative disorders, and
allergic diseases, targeting PTM of immune factors may be a valuable strategy to treat such diseases.
In this research topic, we welcome both original research articles and reviews that will address the significance
of PTMs and immune regulation. We invite researchers to discuss the key molecular mechanisms as well as
drug development in response to PTMs and/or immunity. A better understanding of such mechanisms may
help identify new therapeutic targets for human complex diseases such as cancer, cardiovascular,
neurodegenerative disorders, and allergic diseases, and therefore provide unique opportunities for drug
discovery.
Potential topics include, but are not limited to:
• PTM-related mechanism in the pathogenesis of inflammatory immune diseases
• Development & discovery of inhibitors of immune checkpoints for treating immune diseases
• Drug discovery targeting PTMs of key proteins and the mechanism of action
• Experimental approaches for the identification of interplay of PTMs and immunogenicity
Posttranslational modification (PTM) refers to the covalent chemical modifications of proteins after protein
biosynthesis. PTM mainly consists of methylation, phosphorylation, acetylation, ubiquitylation, SUMOylation,
glycosylation, and ADP-ribosylation. PTM is crucial to the structure and function of the protein, and nearly
affects all aspects of cell biology and pathogenesis. Identification and characterization of PTM to specific
modifications on proteins are essential to discern the functional significance in biological contexts. On the
other hand, innate and adaptive immune responses play a critical role in the development of human diseases.
Immunotherapy has emerged as an attractive approach to treating complex diseases by activating the immune
system.
In recent years, many findings have shown that PTMs are closely associated with immune regulation by
affecting immune cellular function and metabolic reprogramming. For instance, PTMs could promote PD-L1
mediated tumor immune escape by disrupting the protein stability to block the binding of PD-1 and PD-L1,
thus promoting autoimmune responses. Given that PTM of immune factors is closely related to the
pathogenesis and development of diseases such as cancer, cardiovascular, neurodegenerative disorders, and
allergic diseases, targeting PTM of immune factors may be a valuable strategy to treat such diseases.
In this research topic, we welcome both original research articles and reviews that will address the significance
of PTMs and immune regulation. We invite researchers to discuss the key molecular mechanisms as well as
drug development in response to PTMs and/or immunity. A better understanding of such mechanisms may
help identify new therapeutic targets for human complex diseases such as cancer, cardiovascular,
neurodegenerative disorders, and allergic diseases, and therefore provide unique opportunities for drug
discovery.
Potential topics include, but are not limited to:
• PTM-related mechanism in the pathogenesis of inflammatory immune diseases
• Development & discovery of inhibitors of immune checkpoints for treating immune diseases
• Drug discovery targeting PTMs of key proteins and the mechanism of action
• Experimental approaches for the identification of interplay of PTMs and immunogenicity
