Peroxisome Biology: Breakthroughs, Challenges and Future Directions

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Maya Schuldiner

Weizmann Institute of Science

Weizmann Institute of Science

Peter Kijun Kim

Hospital for Sick Children, University of Toronto

University of Hamburg

Michael Sattler

Technical University of Munich

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Peroxisomes are organelles that perform a diversity of metabolic functions in both anabolism and catabolism of cellular building blocks. The importance of peroxisomes for normal development and growth is evident from the existence of a large number of peroxisomal disorders with dramatic phenotypes. Furthermore, peroxisomes have recently been described as potential contributors to the etiology of Alzheimer’s and Parkinson’s diseases, aging, cancer, and type II diabetes.

In recent years, our understanding of peroxisome biogenesis, inheritance, functions, protein targeting, contact sites and diseases has dramatically increased. Moreover, it is clear that the interest in peroxisomes is rapidly expanding as their central regulatory roles are becoming clearer.

This Research Topic aims to bring together leading scientists from the various areas of peroxisome biology – cell biology, genetics, synthetic biology, structural biology, biochemistry, systems biology, physiology and medicine. The collection will include research papers, protocols, opinion pieces, hypothesis papers and reviews dedicated to discussing new methodologies, novel data and the challenges and future directions in the field of peroxisome biology.

By enabling leading scientists in the peroxisome arena to contribute to the Research Topic we hope to drive forward the field of peroxisome biology, discuss and solve open questions in the field, and enable scientists that are interested in peroxisomes to join this exciting field of study. Moreover, by furthering our understanding of this organelle, we aim to support the creation of methods for earlier diagnosis and potential treatment of peroxisome-related diseases.

Illustration provided by Dr Yuri Bykov from Weizmann Institute of Science Rehovot, Israel

Peroxisomes are organelles that perform a diversity of metabolic functions in both anabolism and catabolism of cellular building blocks. The importance of peroxisomes for normal development and growth is evident from the existence of a large number of peroxisomal disorders with dramatic phenotypes. Furthermore, peroxisomes have recently been described as potential contributors to the etiology of Alzheimer’s and Parkinson’s diseases, aging, cancer, and type II diabetes.

In recent years, our understanding of peroxisome biogenesis, inheritance, functions, protein targeting, contact sites and diseases has dramatically increased. Moreover, it is clear that the interest in peroxisomes is rapidly expanding as their central regulatory roles are becoming clearer.

This Research Topic aims to bring together leading scientists from the various areas of peroxisome biology – cell biology, genetics, synthetic biology, structural biology, biochemistry, systems biology, physiology and medicine. The collection will include research papers, protocols, opinion pieces, hypothesis papers and reviews dedicated to discussing new methodologies, novel data and the challenges and future directions in the field of peroxisome biology.

By enabling leading scientists in the peroxisome arena to contribute to the Research Topic we hope to drive forward the field of peroxisome biology, discuss and solve open questions in the field, and enable scientists that are interested in peroxisomes to join this exciting field of study. Moreover, by furthering our understanding of this organelle, we aim to support the creation of methods for earlier diagnosis and potential treatment of peroxisome-related diseases.

Illustration provided by Dr Yuri Bykov from Weizmann Institute of Science Rehovot, Israel

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Editors

Maya Schuldiner

Weizmann Institute of Science

Weizmann Institute of Science

Peter Kijun Kim

Hospital for Sick Children, University of Toronto

University of Hamburg

Michael Sattler

Technical University of Munich

Impact

156,094 Total views

113,404 Article views

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Frontiers in Cell and Developmental Biology

Membrane Traffic and Organelle Dynamics

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