Intramural Vascular Cells: Key Therapeutic Targets for Vascular Cognitive Impairment

138K

views

104

authors

15

articles

Intramural Vascular Cells: Key Therapeutic Targets for Vascular Cognitive Impairment

138K

views

104

authors

15

articles

Editorial

30 October 2020

Editorial: Intramural Vascular Cells: Key Therapeutic Targets for Vascular Cognitive Impairment

Satoshi Saito

,

JoAnne McLaurin

and

Roxana Octavia Carare

2,237 views

1 citations

Editors

3

Roxana Octavia Carare

University of Southampton

JoAnne McLaurin

Sunnybrook Research Institute

National Cerebral and Cardiovascular Center (Japan)

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The dysfunction of the cerebral vasculature is key for the pathogenesis of cognitive impairment and the general term used for this is vascular cognitive impairment.

Recent evidence points to different problems associated with the cerebral arteries as central pathogenic features of Alzheimer’s disease as well as vascular dementia. The NIH has recognised this in the recent Alzheimer’s Disease and Related Dementias summit March 2019 and research priorities have been set for basic mechanisms as well as clinical evidence for the role of vascular factors in the pathogenesis of dementias. The contractile cells within the walls of capillaries are pericytes and in the walls of arteries are vascular smooth muscle cells, with unique intrinsic control within the cerebral parenchyma, different to the innervation of arteries outside the brain. As cerebral vessels are the anatomical substrate for both perfusion of the brain as well as clearance of peptides that aggregate in neurodegenerative diseases, they represent attractive targets for treatment.

This Research Topic aims to provide a review of the morphological, physiological, pathological, radiological and clinical evidence for mural cells as novel therapeutic targets for vascular cognitive impairment.

The dysfunction of the cerebral vasculature is key for the pathogenesis of cognitive impairment and the general term used for this is vascular cognitive impairment.

Recent evidence points to different problems associated with the cerebral arteries as central pathogenic features of Alzheimer’s disease as well as vascular dementia. The NIH has recognised this in the recent Alzheimer’s Disease and Related Dementias summit March 2019 and research priorities have been set for basic mechanisms as well as clinical evidence for the role of vascular factors in the pathogenesis of dementias. The contractile cells within the walls of capillaries are pericytes and in the walls of arteries are vascular smooth muscle cells, with unique intrinsic control within the cerebral parenchyma, different to the innervation of arteries outside the brain. As cerebral vessels are the anatomical substrate for both perfusion of the brain as well as clearance of peptides that aggregate in neurodegenerative diseases, they represent attractive targets for treatment.

This Research Topic aims to provide a review of the morphological, physiological, pathological, radiological and clinical evidence for mural cells as novel therapeutic targets for vascular cognitive impairment.

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Editors

Roxana Octavia Carare

University of Southampton

JoAnne McLaurin

Sunnybrook Research Institute

National Cerebral and Cardiovascular Center (Japan)

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Published In

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Frontiers in Aging Neuroscience

Neuroinflammation and Neuropathy, Alzheimer's Disease and Related Dementias, Neurocognitive Aging and Behavior, Cellular and Molecular Mechanisms of Brain-aging, Parkinson’s Disease and Aging-related Movement Disorders, Aging Neuroscience Archive

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Frontiers in Genetics

Genetics of Aging

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