About this Research Topic
Noncoding RNAs (ncRNAs) are involved in the regulation of various cell processes, including transcription, intracellular trafficking, and chromosome remodeling. Their dysregulation has been associated with the development and progression of various types of cancers, which makes them promising cancer biomarkers. In recent years, the detection of cancer-associated ncRNAs in body fluids of cancer patients has proven itself as a particularly valuable method to effectively diagnose cancer. Cancer prognosis employing circulating ncRNAs is preferential when compared to traditional tumor tissue biopsies, especially due to their noninvasiveness, and have great potential for routine application in clinical practice. Thus, this article collection focuses on summarizing the perspectives of ncRNAs as biomarkers in cancer, based on evaluating their expression profiles determined in body fluids of cancer patients.
The stability of ncRNAs in body fluids of cancer patients has not been thoroughly explored. Although several studies have demonstrated that ncRNAs, unlike lncRNAs, are highly stable under diverse temperature and storage conditions, our understanding of the former is still at the initial stages, especially for the more recently detected ncRNAs such as microRNA, lncRNAs, piRNAs, and circRNAs.
In this Research Topic, we would like to present the recent advances on the roles of ncRNAs on tumorigenesis, metastasis, chemoresistance, radioresistance as well as their potential clinical applications in solid cancers. We welcome the submission of Original Research, Review and Systematic Review articles dedicated to:
1) The mechanisms of ncRNAs in cancer development and progression
2) Large scale analysis of ncRNAs
3) Identification and validation the ncRNA prognostic model for cancers by TCGA, GEO or original data
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.