About this Research Topic
Despite decades of studies associating a low vitamin D status with detrimental disease outcomes that cover the whole landscape of neurological diseases, the role of vitamin D in these disorders is a controversial issue. Since clinical trials are sparsely performed, mostly underpowered, and mostly negative on their primary endpoints, a role of vitamin D supplements remains unsubstantiated in the management of patients suffering from stroke, multiple sclerosis, Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis among other diseases.
In this Research Topic, we welcome articles from study groups exploring associations of vitamin D status or relevant genetic profiles with disease-relevant clinical, imaging or laboratory outcomes. Pre-clinical and experimental studies will also be considered. Both positive and negative supplementation studies and randomized controlled trials exploring effects of vitamin D supplements on these outcomes are explicitly welcomed.
With this collection, we also aim to bring together data on relevant outcomes, responder selection, and dose-finding studies covering the whole range of neurological diseases associated with a low vitamin D status. We would therefore like to help better define:
- The relationships between Vitamin D and the pathophysiology of neurological disorders;
- The influence of Vitamin D deficiency on the phenotype of the patients;
- The exact place of Vitamin D as a therapy in those diseases.
This will enable the creation of common knowledge across disciplines, and the selection of participants and outcomes for the development of efficient clinical supplementation trials.
Keywords: Vitamin D, Pathophysiology, Trial, Neurodegeneration, Neuroinflammation
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.