Genetics Architecture and Underlying Molecular Mechanisms in Host-Pathogen Interactions

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Editorial

18 August 2021

Editorial: Genetics Architecture and Underlying Molecular Mechanisms in Host-Pathogen Interactions

Benjamin L. Makepeace

,

Androniki Psifidi

,

Diego Robledo

and

Dong Xia

1,829 views

1 citations

Editors

4

Dong Xia

Royal Veterinary College (RVC)

Androniki Psifidi

Royal Veterinary College (RVC)

Diego Robledo

Roslin Institute, University of Edinburgh

Benjamin Makepeace

University of Liverpool

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About

Dynamic host-pathogen interactions determine the outcome of infections, clinical sequelae and the success of prophylactic or therapeutic treatments. The use of a wide variety of molecular and cell biology tools such as advanced microscopy, -omics techniques, as well as data analysis capacities facilitated by advanced statistical and machine learning algorithms have increased our understanding in host-pathogen interactions. However, the explicit underlying molecular mechanisms remain elusive or unexplored. This has restrained the development of novel disease intervention strategies. The identification of host genes and key pathogen-interacting factors by a genome-wide genetic expression, epigenetic profiling, and other emerging technologies as well as the dissection of the role of microbiome composition should provide important insights to combating infectious diseases.

This Research Topic aims to present state-of-the-art research and future directions for host-pathogen interactions. Specifically, we encourage the submission of reviews, original research, and method articles, as well as perspective articles, in the following (but not limited to) topics:

• Host genetic variation (structural variants, CNVs, and SNPs) that conditions the outcome of pathogen (such as virus, bacteria, etc.) infections
• Host functional genomics studies (transcriptomic, proteomic, epigenetic, etc.) that shed light into the mechanisms shaping infection processes
• Host microbiome composition and its effect on the pathogen load
• Systems biology approaches integrating the “omics” of infection and host responses
• Utilization of cellular systems, animal models, or single cell analyses to interrogate host genetic control of pathogenesis
• Genetic factors that control innate and adaptive immune responses to pathogens
• Genetic and epigenetic factors that affect host immune response to vaccine and treatments

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Editors

Dong Xia

Royal Veterinary College (RVC)

Androniki Psifidi

Royal Veterinary College (RVC)

Diego Robledo

Roslin Institute, University of Edinburgh

Benjamin Makepeace

University of Liverpool

Impact

101,199 Total views

73,025 Article views

25,722 Article downloads

2,452 Topic views

Published In

Frontiers in Genetics

Livestock Genomics, Applied Genetic Epidemiology, Systems Biology Archive

Frontiers in Microbiology

Infectious Agents and Disease

Frontiers in Veterinary Science

Livestock Genomics

Frontiers in Psychiatry

Systems Biology Archive

Frontiers in Physiology

Systems Biology Archive

Frontiers in Neuroscience

Systems Biology Archive

Frontiers in Bioengineering and Biotechnology

Systems Biology Archive

Frontiers in Cell and Developmental Biology

Systems Biology Archive

Frontiers in Applied Mathematics and Statistics

Systems Biology Archive

Frontiers in Medicine

Infectious Agents and Disease

Frontiers in Public Health

Infectious Agents and Disease

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