Targeting Cardiac Proteotoxicity

189.3K

views

62

authors

14

articles

Editorial

25 March 2021

Editorial: Targeting Cardiac Proteotoxicity

Mark J. Ranek

,

Md. Shenuarin Bhuiyan

and

Xuejun Wang

2,324 views

1 citations

Editors

4

Xuejun Wang

Sanford School of Medicine, University of South Dakota

Hui-Hua Li

Beijing Chaoyang Hospital, Capital Medical University

Md. Shenuarin Bhuiyan

Louisiana State University Health Shreveport

Mark J. Ranek

Johns Hopkins University

Impact

About

There is a preponderance of evidence that the progression from a large subset of human heart diseases to heart failure (HF) involves increased proteotoxic stress (IPTS); and experimental studies are demonstrating that targeting IPTS could be a novel and effective strategy for HF intervention, including both HF with reduced ejection fraction (EF) and HF with preserved EF. However, the significance of proteotoxicity in cardiac pathophysiology remains underappreciated and, importantly, none of the current clinical therapies for HF are intended to target IPTS yet, calling for increasing our effort to educate the biomedical community on this nascent and exciting field.

In the past several years, exciting new progresses have been made at multiple levels (e.g., proteomics, molecular/cell biology, and integrative physiology) regarding the underlying causes and mechanisms of action of IPTS in diseased hearts as well as novel strategies to facilitate the clearance of toxic protein species by both proteasomes and lysosomes. This Research Topic is intended to timely highlight these cutting-edge multi-disciplinary sciences, stimulate new ideas, entice more researchers to join the field, and move forward this underappreciated but highly significant field. Both Original Research and Review articles are welcomed.

Download ebook

PDF

EPUB

Share

Editors

Xuejun Wang

Sanford School of Medicine, University of South Dakota

Hui-Hua Li

Beijing Chaoyang Hospital, Capital Medical University

Md. Shenuarin Bhuiyan

Louisiana State University Health Shreveport

Mark J. Ranek

Johns Hopkins University

Impact

189,280 Total views

160,542 Article views

27,317 Article downloads

1,421 Topic views

Published In

Frontiers in Physiology

Striated Muscle Physiology, Clinical and Translational Physiology

Frontiers in Cardiovascular Medicine

Heart Failure and Transplantation

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Suggest a topic