About this Research Topic
Many chronic complex diseases such as cancer, diabetes, and asthma are being redefined as heterogeneous and the deregulation of the immune system is at the heart of many of these diseases. Due to the complexity of the immune system, it has become evident that a multidisciplinary approach is essential for gaining a thorough understanding of the mechanisms involved in modulating the immune system in various diseases. Systems immunology brings together methodologies and tools from the fields of mathematics, engineering, physics, and computer science to gain a better understanding of the control, regulation and feedback loops within the immune system and how these processes are implicated in disease, from early to advanced stages.
In the context of cancer, systems immunology approaches are now enabling us to gain insight into the dynamics between the immune system and the tumor microenvironment and how differential regulation of immune responses contribute to the pathogenesis of cancer and patient outcome. These approaches are highly promising for accelerating the identification of more effective immunotherapeutic molecules, such as immuno-modulatory antibodies, that can be used to treat and potentially eliminate cancer. In addition, the use of systems immunology can provide beneficial insights into how targeted cancer therapies such as photodynamic (PDT) and sonodynamic (SDT) therapy, as well as photochemical internalization (PCI) affect anti-tumor immune responses and the composition of the tumor microenvironment.
This Research Topic will focus on the application of systems immunology approaches to better understand how the immune system is hijacked in cancer and the dynamics within the tumor immune microenvironment. We aim to discuss how systems immunology approaches can be used to analyze and further develop therapeutic modalities for cancer, with a key focus on immunotherapies and energy-based therapies. In addition, we will discuss new methods and tools that can be applied to immunological data, including OMICs data, to better understand the regulation of the immune system in cancer. We welcome the submission of Original Research, Review and Mini-Review articles covering the following topics:
1. Systems immunology approaches to explore the role of the immune microenvironment in cancer and how immune cell populations can be therapeutically modulated.
2. The use of systems immunology to explore how the immune microenvironment exerts selection pressure during early stages of cancer.
3. Development and application of tools, algorithms, and techniques that can be used to gain a deeper understanding of immune regulation in healthy versus cancer patients.
4. Systems immunology approaches for identifying novel immunotherapeutic targets for the treatment of cancer.
5. Application of systems immunology to investigate immune responses resulting from various therapeutic strategies including energy-based therapies such as PDT, SDT and PCI.
6. Application of systems immunology to study alterations in the immune system in response to chemotherapy and immunotherapies.
7. Using systems immunology-based methods and tools to identify early diagnostic immunological biomarkers for various cancers.
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.