Mechanisms controlling the packaging of the genetic material into chromatin are central during normal and disease development. At the most fundamental level, the DNA is wrapped around histone proteins to create nucleosomes which are constantly modified and acted upon to allow for effective regulation of transcription and maintenance of the cellular state. Accordingly, in recent years, multiple chromatin modifiers and remodelers have emerged as causal factors and promising drug targets for numerous pathologies. As such, an in-depth understanding of the mechanisms required for effective regulation of chromatin states during healthy and pathological growth is essential.
The advent of effective sequencing approaches has enabled immense progress in our understanding of chromatin biology in recent years. However, the deployment of complementary approaches to integrate the dynamic interplays shaping the chromatin environment remains to be achieved. Here we wish to highlight innovative approaches employed by researchers to uncover novel biological insights in chromatin structure and function as well as transcriptional regulation in both healthy and diseased states.
In this Research Topic, we aim to gather articles employing quantitative approaches to uncover novel insights into chromatin biology by focusing on emerging proteomics, genomics, biochemical and imaging techniques. Original research manuscript, brief reports, mini-reviews and reviews will be welcomed. Some of the potential topics include:
• Quantification of the contribution of histone protein modifications to chromatin biology and transcriptional regulation.
• Methods to investigate the physical interplay between chromatin and transcription.
• Phase separation and its impact on chromatin biology.
• Technical considerations for the study of chromatin structure and function regulation in health and disease states.
• Emerging tools to alter the chromatin structure and function.
Mechanisms controlling the packaging of the genetic material into chromatin are central during normal and disease development. At the most fundamental level, the DNA is wrapped around histone proteins to create nucleosomes which are constantly modified and acted upon to allow for effective regulation of transcription and maintenance of the cellular state. Accordingly, in recent years, multiple chromatin modifiers and remodelers have emerged as causal factors and promising drug targets for numerous pathologies. As such, an in-depth understanding of the mechanisms required for effective regulation of chromatin states during healthy and pathological growth is essential.
The advent of effective sequencing approaches has enabled immense progress in our understanding of chromatin biology in recent years. However, the deployment of complementary approaches to integrate the dynamic interplays shaping the chromatin environment remains to be achieved. Here we wish to highlight innovative approaches employed by researchers to uncover novel biological insights in chromatin structure and function as well as transcriptional regulation in both healthy and diseased states.
In this Research Topic, we aim to gather articles employing quantitative approaches to uncover novel insights into chromatin biology by focusing on emerging proteomics, genomics, biochemical and imaging techniques. Original research manuscript, brief reports, mini-reviews and reviews will be welcomed. Some of the potential topics include:
• Quantification of the contribution of histone protein modifications to chromatin biology and transcriptional regulation.
• Methods to investigate the physical interplay between chromatin and transcription.
• Phase separation and its impact on chromatin biology.
• Technical considerations for the study of chromatin structure and function regulation in health and disease states.
• Emerging tools to alter the chromatin structure and function.