Research Topic

Organization and Functional Properties of the Blood Brain Barrier

  • Submission closed.

About this Research Topic

The blood brain barrier (BBB) is composed of cerebral capillaries, and some adjacent larger blood vessels, possessing specialized polarized endothelial cells with high electrical resistance due to the presence of tight junctions. The endothelial cells mediate transport processes between the blood and brain, ...

The blood brain barrier (BBB) is composed of cerebral capillaries, and some adjacent larger blood vessels, possessing specialized polarized endothelial cells with high electrical resistance due to the presence of tight junctions. The endothelial cells mediate transport processes between the blood and brain, and thereby serve to control brain extracellular fluid homeostasis. Barrier functions may be influenced by perivascular cells including astrocytes, pericytes, microglia, and neurons, collectively referred to as the neurovascular unit.

There is current evidence that several central nervous system disorders are associated with BBB malfunction. Thus, defining the specific properties of BBB endothelial cells, and their regulation by perivascular elements, is of great importance in understanding brain pathophysiology.

We propose a group of articles that illustrate dynamic aspects of BBB function and disease, including a brief historical introduction providing an overview; an overview of functional differences between the luminal (blood-facing) and abluminal (brain-facing) plasmalemmal domains of the polarized endothelial cells; a description of the junctional complexes that impart a high electrical resistance to the barrier; and a review of transport processes for solutes including glucose, amino acids, electrolytes, and peptides. Furthermore, mechanisms for regulating barrier function will be reviewed, and strategies for drug delivery will be discussed. Finally, BBB malfunction associated with key central nervous system disorders will be described.

Topic Editor Darryl Peterson is owner of Harbor Biotechnology, LLC, and has been awarded patents related to the treatment of stroke. All other Topic Editors declare no competing interests with regard to the Research Topic subject.


Keywords: blood brain barrier


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Recent Articles

Loading..

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Topic Editors

Loading..

Submission Deadlines

Submission closed.

Participating Journals

Loading..

Topic Editors

Loading..

Submission Deadlines

Submission closed.

Participating Journals

Loading..
Loading..

total views article views article downloads topic views

}
 
Top countries
Top referring sites
Loading..