About this Research Topic
1) How can we optimize host defenses against opportunistic infections and unwanted lymphoproliferation?
2) How do we minimize immune-mediated attack on the host?
3) How do we maintain stable donor hematopoiesis to ensure correction of the underlying disease?
This Research Topic will explore our current understanding of how the transplanted graft and the emerging donor immune system interface with the host leading to the scope of challenges we experience in the clinical transplant arena. We will review the current state of transplant medicine within this scope and highlight the obstacles that currently impede the broader use of this technology to treat human disease. As advances move forward with regard to gene therapy, conventional HSCT may lose its attractiveness as a therapeutic option. Further enhancements in transplant medicine to address the topics discussed in this issue will be needed to retain this treatment modality as a viable option for patients with life threatening hematopoietic-based disease.
We welcome the submission of Review, Mini-Review, Original Research, and Perspective articles covering the following topics:
1. Immune reconstitution.
2. Cgvhd.
3. Mesenchymal stem cells.
4. Late infections and adoptive immunotherapy strategies.
5. Autoimmune disease.
6. Post-Transplant Lymphoproliferative Disease.
7. Chimerism.
8. Graft rejection, late rejection.
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.