About this Research Topic
• Flavonoids
• Chalcones
• Benzodiazepines
• Aryl indoles
• Bisaryls
• Quinolines
• Curcuminoids
These molecules have various advantages, including rapid accessibilities to find hits for the targets, and structural rigidities to improve on-target effects. This indicates that the approach by screening the privileged structure-derived chemical library might be a viable strategy to improve the productivity of the drug discovery process, especially for the initial stages of the process. For example, synthetic flavonoids such as Alvocidib and Voruciclib are currently investigated as novel CDK9 inhibitors under clinical trials for the treatment of malignant tumors. Thus, considering all of those, the development of synthetic methodologies for privileged natural product scaffolds would be a very important and worthwhile Research Topic. This Research Topic will introduce diverse natural product scaffolds and their preparation methods with novelty and feasibility for successful drug discovery.
• Novel synthetic methodology for privileged scaffolds
• Total synthesis of natural products
• Chemical genetics studies using chemical libraries of privileged scaffolds
• Medicinal chemistry works using privileged scaffolds
Keywords: Methodologies, Privileged, Natural Product, Synthesis, Flavonoids
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