Research Topic

Involvement of Human Papilloma Virus in the Development of Head & Neck Squamous Cell Carcinoma

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About this Research Topic

Head and neck squamous cell carcinomas (HNSCCs) represent the sixth most common cancer worldwide, with about 550.000 new cases diagnosed each year. In addition to tobacco and alcohol abuse, infection with oncogenic human papillomavirus (HPV) has also been proposed as a new risk factor of these cancers. ...

Head and neck squamous cell carcinomas (HNSCCs) represent the sixth most common cancer worldwide, with about 550.000 new cases diagnosed each year. In addition to tobacco and alcohol abuse, infection with oncogenic human papillomavirus (HPV) has also been proposed as a new risk factor of these cancers. Approximately 20 to 25% of HNSCCs, and about 50% of oropharyngeal carcinomas patients have been found to been infected with the virus. Over the past several years, some countries have reported an increase of HPV16-related oropharyngeal cancers in non-smoker and non-drinking younger people. HNSCCs caused by tobacco and alcohol abuse may differ from HNSCCs induced by HPV, which leads researchers to consider them as two biologically distinct cancers. The occurrence of HPV infection impacts the prognostic of the patient; however, there are still controversies about the anatomic localization and the presence of some cofactors.

The aim of this Research Topic is to shed light on the last researches about the involvement of HPV infection in the development of HNSCC, and the related impact on prognostic outcomes of the cancer type. We welcome Original Research and Review articles focused, but not limited to:

1) Prognostic value of immune cells in Head and Neck carcinoma.
2) HPV basic science mechanisms in Head and Neck carcinoma.
3) Blood peripheral immune cells in HPV-induced Head and Neck carcinoma.


Keywords: HPV, cancer, head, neck, Squamous cell carcinoma


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