Background: CTG remains the only non-invasive tool available to the maternity team for continuous monitoring of fetal well-being during labour. Despite widespread use and investment in staff training, difficulty with CTG interpretation continues to be identified as a problem in cases of fetal hypoxia, which often results in permanent brain injury. Given the recent advances in AI, it is hoped that its application to CTG will offer a better, less subjective and more reliable method of CTG interpretation.

Objectives: This mini-review examines the literature and discusses the impediments to the success of AI application to CTG thus far. Prior randomised control trials (RCTs) of CTG decision support systems are reviewed from technical and clinical perspectives. A selection of novel engineering approaches, not yet validated in RCTs, are also reviewed. The review presents the key challenges that need to be addressed in order to develop a robust AI tool to identify fetal distress in a timely manner so that appropriate intervention can be made.

Results: The decision support systems used in three RCTs were reviewed, summarising the algorithms, the outcomes of the trials and the limitations. Preliminary work suggests that the inclusion of clinical data can improve the performance of AI-assisted CTG. Combined with newer approaches to the classification of traces, this offers promise for rewarding future development.

Late intrauterine growth restriction (IUGR) is a fetal pathological condition characterized by chronic hypoxia secondary to placental insufficiency, resulting in an abnormal rate of fetal growth. This pathology has been associated with increased fetal and neonatal morbidity and mortality. In standard clinical practice, late IUGR diagnosis can only be suspected in the third trimester and ultimately confirmed at birth. This study presents a radial basis function support vector machine (RBF-SVM) classification based on quantitative features extracted from fetal heart rate (FHR) signals acquired using routine cardiotocography (CTG) in a population of 160 healthy and 102 late IUGR fetuses. First, the individual performance of each time, frequency, and nonlinear feature was tested. To improve the unsatisfactory results of univariate analysis we firstly adopted a Recursive Feature Elimination approach to select the best subset of FHR-based parameters contributing to the discrimination of healthy vs. late IUGR fetuses. A fine tuning of the RBF-SVM model parameters resulted in a satisfactory classification performance in the training set (accuracy 0.93, sensitivity 0.93, specificity 0.84). Comparable results were obtained when applying the model on a totally independent testing set. This investigation supports the use of a multivariate approach for the in utero identification of late IUGR condition based on quantitative FHR features encompassing different domains. The proposed model allows describing the relationships among features beyond the traditional linear approaches, thus improving the classification performance. This framework has the potential to be proposed as a screening tool for the identification of late IUGR fetuses.

Non-invasive fetal electrocardiography represents a valuable alternative continuous fetal monitoring method that has recently received considerable attention in assessing fetal health. However, the non-invasive fetal electrocardiogram (ECG) is typically severely contaminated by a considerable amount of various noise sources, rendering fetal ECG denoising a very challenging task. This work employs a deep learning approach for removing the residual noise from multi-channel fetal ECG after the maternal ECG has been suppressed. We propose a deep convolutional encoder-decoder network with symmetric skip-layer connections, learning end-to-end mappings from noise-corrupted fetal ECG signals to clean ones. Experiments on simulated data show an average signal-to-noise ratio (SNR) improvement of 9.5 dB for fetal ECG signals with input SNR ranging between −20 and 20 dB. The method is additionally evaluated on a large set of real signals, demonstrating that it can provide significant quality improvement of the noisy fetal ECG signals. We further show that employment of multi-channel signal information by the network provides superior and more reliable performance as opposed to its single-channel network counterpart. The presented method is able to preserve beat-to-beat morphological variations and does not require any prior information on the power spectra of the noise or the pulse location.