Research Topic

The Role of Biomembranes and Biophysics in Immune Cell Signaling

About this Research Topic

Biomembranes, particularly the plasma membrane, take part in the very first steps of the immune responses, as they provide a structural platform that integrates biophysical and biochemical signals necessary for immune receptors to recognize their ligands as well as other sensing mechanisms for immune activation. Biomembranes’ dynamics and biophysical properties in forms of curvature, molecular ordering, and forces have, thus, a significant impact on the immune receptors activation and signal transduction, for instance for T-cell receptor signaling, B-cell receptor signaling, Fc-receptor signaling, and other signaling cascades. Traditional biochemistry or molecular and cellular imaging, however, usually have a low spatial and temporal resolution, and hence do not allow to study dynamic regulations on immune receptor functions. Due to lack of mastery in precision and quantitative tools, the biophysical aspect of immunity, including biological forces, electrostatic interactions and sub-diffraction/real-time molecular dynamics, has often been overlooked in immunology over the past years. At the cellular or nanoscale level, no systemic effects have been exerted to develop an integrated understanding of how biophysical aspects of cell biology operate to mediate immune functions.

With new technological advancements in biophysics, the study of biomembranes’ structure and dynamics in immunology is gaining momentum in both quality and quantity, opening for new prospects in the understanding of immune response regulation. In sharp contrast with other newly emerging immunology frontlines that are rapidly coming into distinctive focal points of public discussions, such as single-cell analysis and host-microbe symbiosis, work on biophysics and biomembranes is somewhat diffused, which hinders the collective development of this particular line of investigation.

This collection aims to provide an overview of the current advances in the understanding of the role of biomembranes composition, dynamics and interaction in the activation of immune response, with a particular focus on the latest cutting-edge technological approaches.

In this Research Topic, we welcome submissions of Original Research articles, Reviews, Opinions and Methods articles aimed to understand how the immunological cascade starting from immune receptors is influenced by:

• Biophysical forces
• Membrane dynamics
• Membrane-cytoskeleton interactions
• Nanoscale molecular interactions
• Lipid domains
• Phase separation

This collection particularly welcomes innovative tools, emerging approaches and ground-breaking ideas aimed to integrate biophysics and immunology research.


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Biomembranes, particularly the plasma membrane, take part in the very first steps of the immune responses, as they provide a structural platform that integrates biophysical and biochemical signals necessary for immune receptors to recognize their ligands as well as other sensing mechanisms for immune activation. Biomembranes’ dynamics and biophysical properties in forms of curvature, molecular ordering, and forces have, thus, a significant impact on the immune receptors activation and signal transduction, for instance for T-cell receptor signaling, B-cell receptor signaling, Fc-receptor signaling, and other signaling cascades. Traditional biochemistry or molecular and cellular imaging, however, usually have a low spatial and temporal resolution, and hence do not allow to study dynamic regulations on immune receptor functions. Due to lack of mastery in precision and quantitative tools, the biophysical aspect of immunity, including biological forces, electrostatic interactions and sub-diffraction/real-time molecular dynamics, has often been overlooked in immunology over the past years. At the cellular or nanoscale level, no systemic effects have been exerted to develop an integrated understanding of how biophysical aspects of cell biology operate to mediate immune functions.

With new technological advancements in biophysics, the study of biomembranes’ structure and dynamics in immunology is gaining momentum in both quality and quantity, opening for new prospects in the understanding of immune response regulation. In sharp contrast with other newly emerging immunology frontlines that are rapidly coming into distinctive focal points of public discussions, such as single-cell analysis and host-microbe symbiosis, work on biophysics and biomembranes is somewhat diffused, which hinders the collective development of this particular line of investigation.

This collection aims to provide an overview of the current advances in the understanding of the role of biomembranes composition, dynamics and interaction in the activation of immune response, with a particular focus on the latest cutting-edge technological approaches.

In this Research Topic, we welcome submissions of Original Research articles, Reviews, Opinions and Methods articles aimed to understand how the immunological cascade starting from immune receptors is influenced by:

• Biophysical forces
• Membrane dynamics
• Membrane-cytoskeleton interactions
• Nanoscale molecular interactions
• Lipid domains
• Phase separation

This collection particularly welcomes innovative tools, emerging approaches and ground-breaking ideas aimed to integrate biophysics and immunology research.


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Topic Editors

Loading..

Submission Deadlines

01 June 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..

Topic Editors

Loading..

Submission Deadlines

01 June 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..
Loading..

total views article views article downloads topic views

}
 
Top countries
Top referring sites
Loading..