About this Research Topic
Dendritic cells (DCs) play a critical role in immune system, as they are necessary both for innate and adaptive immunity. According to their function, dendritic cells can be classified in immune tolerogenic or inflammatory DCs. DCs have been shown to regulate T cell-mediated immune responses and lead to immune tolerance and autoimmunity. For example, immune-tolerogenic DCs facilitate the development of regulatory T cells and inhibit T helper 17-mediated autoimmunity in mice with experimental autoimmune encephalomyelitis. Moreover, inflammatory DCs activate CD8+ and CD4+ T cells and elicit T cell-mediated inflammatory immune responses in vivo. However, the molecular and cellular mechanisms underlying DC-mediated immune tolerance and autoimmunity are still obscure.
The purpose of this Research Topic is to define the current advances in understanding the molecular mechanisms through which DCs modulate immune tolerance or autoimmunity. For this purpose, we particularly encourage studies on animal disease models or clinical trials, that will contribute to the future development of clinical treatments using DCs to target human diseases.
In this Research Topic we would like to address the following themes:
• Molecular and cellular mechanisms of DC-mediated immune tolerance;
• Molecular and cellular mechanisms of DC-mediated autoimmunity
• Cellular therapy using immune tolerogenic DCs to treat autoimmune diseases
• DC-mediated immunotherapy to target human diseases using animal models.
• Immune-tolerogenic DCs induced by cancer and viruses.
We welcome the submission of Original Research, Systematic Reviews, Reviews, Mini-reviews, Methods, Hypothesis and Theory, Perspective, General Commentary, Opinion, Case report and Clinical Trials.
Topic Editor Dr. Zhou is employed by Cas Lamvac Biotech Co. Ltd.
The other Topic Editors declare no conflict of interest with regard to the Research Topic theme.
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.