About this Research Topic
Kidney diseases represent a global concern due to its elevated and rapidly growing incidence. Kidney alterations often result as a consequence of existing co-morbidities or due to a primary damage in another organ. On the other hand, kidney diseases might lead to injury and disease of remote organs including the heart, liver, brain, etc. For example, more than 50% of deaths among chronic kidney disease patients are attributable to cardiovascular complications, highlighting the relevance of kidney crosstalk with distant organs. The communication of the kidneys with the heart has long been recognized and more recently several complex interactions have been reported for the kidney with other organs, including brain, liver, spleen, gut and the lungs in physiologic and pathologic renal settings. Nevertheless, the communication mechanisms linking the kidney with distant organ physiology remain to be largely explored and clarified.
This Research Topic will help to understand and compile the novel findings clarifying the cellular and molecular mechanisms underlying the kidney communication with distant organs in physiological situations and during disease, thus helping us to understand how kidney disease affects and induces cardiovascular injury, cardiometabolic diseases, hypertension, diabetes, lung and liver injury, cognitive alterations, etc.
The Research Topic welcomes original articles and review submissions covering the bi-directional communication between the kidneys and the heart, lungs, liver, gut, spleen, brain and nervous system in normal physiology and in pathologic conditions including but not limited to acute kidney injury, chronic kidney disease, kidney transplantation, cardiometabolic associated pathologies and hypertension. Basic animal and cell research as well as translational studies uncovering mechanisms of kidney and distant organ crosstalk are welcome.
Topic Editor Dr. Frédéric Jaisser received grants from Bayer AG and AstraZeneca. All other Topic Editors declare no competing interests with regards to the Research Topic subject.
Keywords: cardiorenal, hepatorenal, kidney disease, cardiometabolic, hypertension
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