About this Research Topic
Herpesviruses, being obligate parasites, hijack the host machinery for their survival and proliferation. They need to trigger modifications in the host's system and thus it would be interesting to acknowledge the various caused changes. Herpesviruses affect and target different organelles of a cell, thereby a particular virus may culminate in different diseases. Herpesviruses are known to induce a wide variety of disorders ranging from neuro-degeneration to carcinomas, which are poles apart, as one represents cell death and the other signifies uncontrolled cellular proliferation. The possible mechanisms, at cellular as well as at molecular levels, adopted and modulated by the viruses in order to achieve these two differential modalities would be interesting to debate. Studies in this field may provide cues in the direction of virus-induced pathogenesis.
Moreover, Herpesviruses in conjunction with different microorganisms and host factors can accelerate or regress a particular disorder. In addition, during evolution, modifications in the molecular entity may have enabled the virus to attain different mechanisms to infect. Cellular changes in Herpesviruses induced diseases influencing the host's metabolomics, signaling pathways. Thus, the conventional techniques adopted to understand the pathogenesis may not be adequate. Our approach needs to be extended beyond the traditional methods in order to understand the pathobiology in a better and more precise manner. Additionally, Herpesvirus pathogenesis may be influenced by an individual's genetics or environment and may significantly contribute to the disease enhancement. There is an urgent need to understand the susceptibility of viruses towards the host cells and the possible contribution of co-factors in disease progression.
In the current Research Topic, we welcome Reviews and Original Research articles including but not limited to the themes listed below:
- Signaling at cellular and molecular levels in Herpesvirus drive abnormalities.
- Mechanistic variations among α, β and γ Herpesviruses in disease progression.
- OMICS approaches to understand host-pathogen interactions with respect to Herpesviruses.
- The role of Herpesviruses in cancer and neurodegeneration.
Keywords: EBV, KSHV, CMV, Herpesvirus, Disease Pathogenesis
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