About this Research Topic
Molecular medicine aiming at disease-modifying treatments of severe pathologies needs deeper understanding in: (i) the subcellular ultrastructures as drug targets, and (ii) the organization of the materials states and phase transitions that can serve for the development of new therapeutic strategies. For the past few years, we have witnessed significant advances in nanoscale studies of hierarchical organizations of biomembranes and their links to the comprehension of Alzheimer’s and other neurodegenerative diseases process.
This Research Topic aims to cover novel research trends of interdisciplinary significance of “Lipid-Protein Mesophases and Cell Organelle Ultrastructure in Health and Disease” by considering a broad range of disciplines, including biophysical chemistry, biological chemistry, system biology, computational biology, and cell and molecular biology.
We welcome studies on advanced approaches in the investigation of mesophase lipid/protein materials for drug delivery purposes, the biogenesis of intracellular membranes and their remodeling in response to stress and multiple diseases conditions, and the involvement of lipid/protein scaffolds in the pathogenesis of neurological diseases. In the framework of multidisciplinary research, this Research Topic will particularly focus on:
• Membrane biophysics and biomolecular self-assembly.
• Membrane shapes, biogenesis and phase transitions induced by stress.
• Role of lipids and proteins in organelle structure and genesis.
• Alzheimer’s disease-related research, microglia and neuro-inflammation.
Submissions of the following article types are welcome: Original Research, Brief Research Report, Methods, Review, Mini Review, Perspective, and Opinion.
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.