About this Research Topic
Cellular senescence is a state of permanent cell cycle arrest associated with extensive phenotypic changes that is found across mammalian species. Although it is over 50 years since Hayflick first described cellular senescence, it is only recently that the widespread and profound impacts that senescent cells have on organismal ageing have become widely accepted. As a consequence there has been a recent exponential expansion of interest in the area, coupled with a drive for rapid translational activity. To support this development, research at all stages of the translational pipeline, from fundamental molecular mechanisms to novel platform technologies to identify interventions specific to senescent cells is currently underway.
Advances in our understanding of the molecular control pathways underpinning entry into, and exit from, senescence, and the environmental and genetic factors that are causal in these processes are necessary to develop effective interventions. Equally, methodology that enables the specific identification of senescent cells, among their growing and quiescent counterparts is required to ensure that future therapeutics can be properly targeted and the effects of manipulation of the senescent population fully understood. The development of broad spectrum anti-degenerative therapeutics requires proper analysis of potential differential cellular effects across multiple tissue types, and even species.
In this Research Topic, we aim to showcase both fundamental and translational advances in our understanding of cellular senescence, which will form the basis of future therapeutics for age-related degenerative changes. This includes, but is not restricted to:
• Phenotypic characterization of senescent cells in novel tissue types and species
• Characterization of extracellular impact of senescent cells
• Development of visualization and identification methods
• Novel molecular mechanisms controlling entry into and exit from senescence
• Methods for screening the effects of potential senotherapeutics
• Synthesis and bioevaluation of novel senotherapeutics
Author guidelines can be found at this link: https://fro.ntiers.in/qd1v
Keywords: Molecular Mechanisms, Senotherapeutics, Ageing, Senolytics, Anti-Degeneratives
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.