Research Topic

Bio-Systems Engineering for Regulating Nerve Regeneration

About this Research Topic

Peripheral nerve injuries often result in pain, neuroma, fibrosis, tingling, numbness, and the irreversible loss of sensory and motor functions. Pathological changes arising from acute or chronic nerve compression/denervation injuries represent a large class of neurological-diseases with a huge socio-economic burden. Existing treatment options include surgical repair, often using autologous nerve grafting, and pharmacological adjuvants such as corticosteroids, non-steroidal anti-inflammatory drugs and analgesic compounds, which all have associated drawbacks and are far from being the optimal form of treatment. Thus, there is great clinical need for developing new and innovative treatment strategies to improve functional recovery, quality of life for patients, and for minimizing the socio-economic burden of these neurological diseases.

Existing therapeutic options are not effective enough for treating acute or chronic nerve injuries. Moreover, the reported experimental strategies have not indicated substantial improvement in the process of nerve regeneration so far. This may be attributed, partly, to single factor based treatment approaches or the lack of bio-systems engineering based approaches to tackle spatio-temporal requirements of the complex process involved in nerve regeneration. Therefore, there is a need to promote bio-systems engineering in the field of nerve repair and regeneration in order to achieve remarkable advances. For this endeavor, we collate recent innovations and advances achieved by established researchers around the world and present them in the form of this Research Topic. This collection will provide a landmark reference for worthy insights for the future research of controlled nerve regeneration.

The Research Topic “Bio-Systems Engineering for Regulating Nerve Regeneration” covers interdisciplinary topics in order to provide a multi-range, state-of-the-art source of information for readers. Multidisciplinary topics are expected to cover, but are not limited to, the following subject areas:

• Engineered biomaterials, tissue engineered grafts, cell and gene therapies, immune-modulation, bioelectronics, key cellular, molecular and biochemical players, and surgical repair approaches that demonstrate a significant improvement in the process of axonal regeneration, path-finding, innervation and functional restoration.

• Studies spanning from in vitro and pre-clinical to clinical studies with new and innovative approaches are invited to contribute.

In line with the journal guidelines, both Review articles and full-length Original Research articles can be accepted for publication in this collection.


Keywords: Peripheral Nerve Injuries, Nerve Regeneration, Nerve Stimulation, Surgical Nerve Regeneration, Bioengineering, Nerve Tissue Engineering


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Peripheral nerve injuries often result in pain, neuroma, fibrosis, tingling, numbness, and the irreversible loss of sensory and motor functions. Pathological changes arising from acute or chronic nerve compression/denervation injuries represent a large class of neurological-diseases with a huge socio-economic burden. Existing treatment options include surgical repair, often using autologous nerve grafting, and pharmacological adjuvants such as corticosteroids, non-steroidal anti-inflammatory drugs and analgesic compounds, which all have associated drawbacks and are far from being the optimal form of treatment. Thus, there is great clinical need for developing new and innovative treatment strategies to improve functional recovery, quality of life for patients, and for minimizing the socio-economic burden of these neurological diseases.

Existing therapeutic options are not effective enough for treating acute or chronic nerve injuries. Moreover, the reported experimental strategies have not indicated substantial improvement in the process of nerve regeneration so far. This may be attributed, partly, to single factor based treatment approaches or the lack of bio-systems engineering based approaches to tackle spatio-temporal requirements of the complex process involved in nerve regeneration. Therefore, there is a need to promote bio-systems engineering in the field of nerve repair and regeneration in order to achieve remarkable advances. For this endeavor, we collate recent innovations and advances achieved by established researchers around the world and present them in the form of this Research Topic. This collection will provide a landmark reference for worthy insights for the future research of controlled nerve regeneration.

The Research Topic “Bio-Systems Engineering for Regulating Nerve Regeneration” covers interdisciplinary topics in order to provide a multi-range, state-of-the-art source of information for readers. Multidisciplinary topics are expected to cover, but are not limited to, the following subject areas:

• Engineered biomaterials, tissue engineered grafts, cell and gene therapies, immune-modulation, bioelectronics, key cellular, molecular and biochemical players, and surgical repair approaches that demonstrate a significant improvement in the process of axonal regeneration, path-finding, innervation and functional restoration.

• Studies spanning from in vitro and pre-clinical to clinical studies with new and innovative approaches are invited to contribute.

In line with the journal guidelines, both Review articles and full-length Original Research articles can be accepted for publication in this collection.


Keywords: Peripheral Nerve Injuries, Nerve Regeneration, Nerve Stimulation, Surgical Nerve Regeneration, Bioengineering, Nerve Tissue Engineering


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

30 June 2020 Abstract
31 October 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

30 June 2020 Abstract
31 October 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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