About this Research Topic
One of the most remarkable processes in nature is the transformation of generic round stem cell to a streamlined spermatozoon that travels a long distance to fertilize the egg, complements it, and activates the program to start a new life. This sperm transformation affects virtually every process and structure of the cell, including the reshaping of the nucleus and repacking of the DNA with protamines instead of histones; formation of new RNA granules; activation haploid specific transcription; remodeling of the protein-based centriole and the formation of a flagellum with unique configuration; reduction and conversion of membrane-bound organelles such as the Golgi and ER to acrosome and residual body; and finally, elimination of most of the cytoplasm. The spermatozoon continues to mature during its transport through the epididymis and along the female reproductive tract. Ultimately, the remarkable transformation produces a spermatozoon that competes to fertilize the egg. Post-fertilization, spermatozoon components compliment the egg and activate embryo development. Abnormalities in sperm differentiation result in infertility, miscarriage, and congenital diseases, and we are just at the beginning of understanding the transgenerational impact of epigenetic information carried by sperm. Sperm undergo hyper evolution due to direct selection by sperm competition resulting in many molecular and structural invocations.
Following the first volume (please check Sperm Differentiation and Spermatozoa Function), this current Research Topic will discuss cutting-edge studies currently being conducted to investigate sperm mechanisms of formation and function as well as the translation of basic research into clinical diagnostic and treatment. We welcome Original Research, Review, and Opinion papers; in vivo, in vitro, and in silico studies; development, physiology, evolution, biophysics, medical, and veterinary perspective. All focused on one cell: the sperm.
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.