About this Research Topic
Currently, there are many ongoing efforts to analyze the effects of repurposed drugs on both cancer prevention and therapy; these drugs include, but are not limited to, non-steroidal anti-inﬂammatory drugs, statins, selective estrogen receptor modulators, cardiovascular drugs, antidepressants, and even antibiotics. Repurposed drugs have been found to block cancer development pathways, optimize the efficiency or decrease the secondary effects of chemotherapy, elicit cell death through different mechanisms, among other anti-cancer functions. However, a clearer understanding of their effect and their possible secondary effects are needed to achieve validation of their not intended, but presumably more useful, anti-cancer function.
This Research Topic welcomes the submission of Original Research and Review articles that cover all aspects of the effects of repurposed drugs or drug repurposing candidates on cancer signaling pathways in vitro and in vivo and computational approaches including the following topics (but not limited to):
-Drug repurposing particularly in vitro and in vivo analysis
-Applications of repositioned drugs as potential anti-cancer drugs
-Applications of repositioned drugs for sensitizing to chemotherapy in several types of cancer
This Research Topic is part one of a two-part series - please also see the collection "Repurposed Drugs Targeting Cancer Signaling Pathways: Clinical Insights to Improve Oncologic Therapies"
Keywords: drug repositioning, cancer, signaling pathways, treatments
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.