Research Topic

Therapeutic Strategies in EGFR Mutant Lung Cancer

About this Research Topic

Lung cancer, specifically non-small-cell lung cancer (NSCLC), remains the leading cause of cancer-related mortality worldwide. It has been shown that the EGFR-dependent pathway is activated in many patients with NSCLC. Small-molecule tyrosine kinase inhibitors (TKIs) are the preferred initial therapy for the treatment of EGFR mutant, advanced NSCLC.

First, second and third-generation EGFR-TKIs are currently approved for the treatment of patients with NSCLC that harbors a sensitizing EGFR mutation. Each TKI has its own characteristics influencing therapeutic efficacy and toxicity. While initially effective, acquired resistance to EGFR-TKI is expected and a small subset of patients exhibit primary resistance to EGFR-TKI therapy. The mechanisms underlying primary and acquired resistance to EGFR-TKI are increasingly complex, often including acquired mutations within the drug target, engagement of ‘bypass’ pathways, intra- and inter-tumoral heterogeneity, coexistent genetic alterations in other cancer-related genes, transformation to other histologic subtypes (squamous and small-cell lung cancer) and many others. A greater understanding of the underlying biology is needed to develop strategies to overcome or prevent TKI resistance. In addition, while immuno-oncology (IO) agents are emerging as an effective treatment option for many patients with NSCLC, outcomes in patients with EGFR mutant NSCLC have been disappointing. Additional research to develop IO therapeutic strategies in EGFR-mutant lung cancer is warranted.

This Research Topic is aimed at elaborating on the progress and controversy in translational and clinical research of EGFR mutant lung cancer. We welcome Original Research contributions, relevant Review articles, Perspective and Opinion articles and unique Case Reports, which are aimed at translational research, biological characteristics, genomics and transcriptomics analysis, epidemiology, diagnosis, drug resistance, new drug development, and prognosis for patients with EGFR mutant NSCLC.


Keywords: EFGR mutant lung cancer, Treatments, Diagnosis criteria, drug resistance, Novel Treatments


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Lung cancer, specifically non-small-cell lung cancer (NSCLC), remains the leading cause of cancer-related mortality worldwide. It has been shown that the EGFR-dependent pathway is activated in many patients with NSCLC. Small-molecule tyrosine kinase inhibitors (TKIs) are the preferred initial therapy for the treatment of EGFR mutant, advanced NSCLC.

First, second and third-generation EGFR-TKIs are currently approved for the treatment of patients with NSCLC that harbors a sensitizing EGFR mutation. Each TKI has its own characteristics influencing therapeutic efficacy and toxicity. While initially effective, acquired resistance to EGFR-TKI is expected and a small subset of patients exhibit primary resistance to EGFR-TKI therapy. The mechanisms underlying primary and acquired resistance to EGFR-TKI are increasingly complex, often including acquired mutations within the drug target, engagement of ‘bypass’ pathways, intra- and inter-tumoral heterogeneity, coexistent genetic alterations in other cancer-related genes, transformation to other histologic subtypes (squamous and small-cell lung cancer) and many others. A greater understanding of the underlying biology is needed to develop strategies to overcome or prevent TKI resistance. In addition, while immuno-oncology (IO) agents are emerging as an effective treatment option for many patients with NSCLC, outcomes in patients with EGFR mutant NSCLC have been disappointing. Additional research to develop IO therapeutic strategies in EGFR-mutant lung cancer is warranted.

This Research Topic is aimed at elaborating on the progress and controversy in translational and clinical research of EGFR mutant lung cancer. We welcome Original Research contributions, relevant Review articles, Perspective and Opinion articles and unique Case Reports, which are aimed at translational research, biological characteristics, genomics and transcriptomics analysis, epidemiology, diagnosis, drug resistance, new drug development, and prognosis for patients with EGFR mutant NSCLC.


Keywords: EFGR mutant lung cancer, Treatments, Diagnosis criteria, drug resistance, Novel Treatments


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

14 September 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

14 September 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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