Research Topic

A Journey Through 50 Years of Structural Bioinformatics in Memoriam of Cyrus Chothia

About this Research Topic

The seminal works of Cyrus Chothia on the relationship between the sequence, structure, function, and evolution of proteins have not only pioneered the field of structural bioinformatics, but also proved to be an enduring source of inspiration for future generations of bioinformaticians. Although the field has rapidly evolved during his 50+ year long career, and particularly so in recent years thanks to the advance of high-throughput technologies and Artificial Intelligence, Cyrus’s work remains current. A number of Cyrus’s scientific outputs, for example the Structural Classification of Proteins (SCOP) or the identification of Antibody Canonical Structures, continue to be widely used and keep setting the basis for novel bioinformatics.

With this collection of articles, we want to pay a tribute to Cyrus’s outstanding career and contribution to the field of structural bioinformatics, as well as to his role in training and inspiring generations of scientists. We would particularly welcome any contribution from his former colleagues and students. Articles in this collection will cover a wide range of subjects to reflect both the multifaceted work of Cyrus and how the field has evolved in recent years. These works will focus on the relationship between the sequence, structure and biology of proteins and have a strong computational and statistical component.

In this Research Topic we welcome the submission of original research, reviews, mini-reviews, opinions, and perspective articles on:

• Protein structure determination
• Structural and functional consequences of sequence mutations
• Classification of protein structures and sequences
• Protein homology
• Antibody structure and function
• Structure-based genome-wide analyses


The cover image for this Research Topic was designed by Claire Marks.


Keywords: Protein structure prediction, Structural genomics, Homology, Antibodies, Protein classification


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

The seminal works of Cyrus Chothia on the relationship between the sequence, structure, function, and evolution of proteins have not only pioneered the field of structural bioinformatics, but also proved to be an enduring source of inspiration for future generations of bioinformaticians. Although the field has rapidly evolved during his 50+ year long career, and particularly so in recent years thanks to the advance of high-throughput technologies and Artificial Intelligence, Cyrus’s work remains current. A number of Cyrus’s scientific outputs, for example the Structural Classification of Proteins (SCOP) or the identification of Antibody Canonical Structures, continue to be widely used and keep setting the basis for novel bioinformatics.

With this collection of articles, we want to pay a tribute to Cyrus’s outstanding career and contribution to the field of structural bioinformatics, as well as to his role in training and inspiring generations of scientists. We would particularly welcome any contribution from his former colleagues and students. Articles in this collection will cover a wide range of subjects to reflect both the multifaceted work of Cyrus and how the field has evolved in recent years. These works will focus on the relationship between the sequence, structure and biology of proteins and have a strong computational and statistical component.

In this Research Topic we welcome the submission of original research, reviews, mini-reviews, opinions, and perspective articles on:

• Protein structure determination
• Structural and functional consequences of sequence mutations
• Classification of protein structures and sequences
• Protein homology
• Antibody structure and function
• Structure-based genome-wide analyses


The cover image for this Research Topic was designed by Claire Marks.


Keywords: Protein structure prediction, Structural genomics, Homology, Antibodies, Protein classification


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

08 July 2020 Abstract
06 November 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

08 July 2020 Abstract
06 November 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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