Research Topic

The Serpin Family in the Cardiovascular System

About this Research Topic

The serpin (SERine Protease INhibitor) superfamily gathers hundreds of proteins linked by a common tertiary fold. Serpins with or without inhibitory activity are involved in the regulation of a wide range of biological processes including blood coagulation, fibrinolysis, apoptosis, cell migration or ...

The serpin (SERine Protease INhibitor) superfamily gathers hundreds of proteins linked by a common tertiary fold. Serpins with or without inhibitory activity are involved in the regulation of a wide range of biological processes including blood coagulation, fibrinolysis, apoptosis, cell migration or inflammatory responses, which make them key factors in the pathophysiology of cardiovascular diseases such as atherosclerosis. Moreover, artificial serpins have been recently developed as therapeutic drugs with potential relevance in different disorders including cardiovascular medicine.

The aim of this research topic is to review the current knowledge and the recent advances on the role of serpins with and without antiprotease activities in cardiovascular diseases and their treatment, in particular regarding their role played in the interactions between coagulation factors- inflammatory- and vascular cells.

All types of article types will be considered for publication: original basic science reports, reviews, methodology papers, and clinical studies. The scope of the Research Topic and specific themes for authors to address include:

• Serpins in Thrombosis & Haemostasis
• Artificial serpins with therapeutic usefulness
• Serpins and apoptotic and inflammatory vascular responses
• Viral serpins and cardiovascular diseases
• Oxidative stress, Lipids and serpins


Keywords: Serpins, Thrombosis, Thrombolysis, Immune responses, Apoptosis


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

30 December 2020 Manuscript
14 January 2021 Manuscript Extension

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

30 December 2020 Manuscript
14 January 2021 Manuscript Extension

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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