About this Research Topic
As a replacing strategy to industrial fishing, aquaculture is an important sector of the food industry. Pathogens including virus, bacteria, and parasite threatens quality and production of aquaculture in the form of extensive farming throughout the world. The overuse or misuse of antibiotics and other drugs in the course of culture generates drug-resistant pathogen, and makes many of the current drugs ineffective, causing huge economic loss and food safety related issues. Moreover, overfeeding aquatic animals with drug causes environmental contamination. Novel strategy, especially eco-friendly strategies, are urgently needed to cope with this situation.
Metabolism plays critical roles in regulating biological processes, not only providing energy and substrates for biosynthesis of macromolecules, but also exerting regulatory roles. The discovery that exogenous metabolites could regulate the biological processes such as reversing antibiotic resistance makes them ideal for developing novel strategies for pathogen control in aquaculture. Hijacking of the metabolic network is a promising approach to develop anti-infective approach to dampen pathogenicity of pathogens, rendering pathogen easy to be cleared by the host. Metabolites are eco-friendly, non-toxic, non-immunogenic, and easy-to-use. Although metabolic regulation is starting to be of great interest in other fields of research, studies focusing on pathogens, especially aquatic pathogens, are still scarce.
We envision that a specific Research Topic, dedicated to metabolic regulation of antibiotic resistance and pathogenicity will contribute to the understanding of the metabolic mechanism underlying drug resistance and pathogenicity. Additionally, this study can represent a step further in identifying metabolites that could be used to reverse drug resistance or counteract pathogenicity.
Areas to be included but not limited to:
-metabolism and drug resistance in aquatic pathogens
-metabolism and pathogenicity in aquatic pathogens
-metabolomics, reprogramming metabolomics, proteomics or other -OMICs regarding metabolism
Keywords: Metabolic regulation, drug resistance, pathogenicity, aquatic pathogens
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