About this Research Topic
Periodontal disease is the most common oral condition of the human population, which affects the connective tissue attachment and the supporting bone around teeth. This multifactorial disease is characterized by a group of inflammatory conditions dependent on the presence of virulent microorganisms. However, despite the current clinical diagnostic parameters, it remains difficult to detect clear etiology and early disease development. In this sense, the identification of biomarkers, which are substances used to indicate a local biologic state and activity, can collaborate with future diagnosis techniques, therapeutic interventions, and preventive protocols for periodontal disease. Until now, no biomarker was able to predict periodontal disease activity and severity. Therefore, combinations of candidate biomarkers have been explored as a way to predict disease activity.
The Periodontics section of Frontiers in Dentistry aims to disseminate pertinent information of candidate biomarkers which can significantly contribute to etiopathogenesis knowledge, diagnosis, and treatment of periodontal diseases and peri-implant diseases. The Editors of this Research Topic encourage the submission of manuscripts exploring the relationship between periodontal and peri-implant status and candidate biomarkers from different sources: blood or serum, saliva, subgingival crevicular fluid, plaque samples, tissue, and exhaled air. These biomarkers can be associated with bone resorption products, connective tissue degradation products, microorganisms and their toxins, enzymes released from host cells, as well as inflammatory and immune responses. Additionally, the research scope can include monitoring progression/recurrence, and treatment compliance to determine treatment efficacy, stage of the disease or to predict treatment responses. Laboratory protocols are considered relevant, including molecular biology, immunohistochemistry, genetic and genomic studies, in vivo, and in vitro protocols in human and animal models.
Keywords: Biomarkers, Periodontitis, Etiology, Pathogenesis, Pathway
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.