Research Topic

The Effect of Carbohydrate Restriction on Cancer and Metabolic Syndrome

About this Research Topic

The popularity of low carbohydrate diets such as the ketogenic diet has recently soared to an unprecedented level. Historically used to treat epilepsy, ketogenic diets have now been widely adopted to achieve rapid weight loss and promoted to help with diabetes management. As well, since cancer cells typically consume more glucose than normal cells (the Warburg Effect), diets that restrict glucose intake may also help prevent or treat cancer. However, one of the major concerns associated with low carbohydrate, high fat diets such as the ketogenic diets are the effect the diet might have on the lipid profile since it can be high in saturated fats, which is associated with an increased risk of cardiovascular disease.

Many claims regarding the benefits of low carbohydrate diets need to be supported by scientific evidence. More studies are required to highlight the safety and efficacy of such diets for treating cancer and metabolic syndrome. Since no two cancers are identical, there is currently a paucity of information on the effect of glucose restriction in the prevention and treatment of different types of cancer. In a very low carbohydrate high-fat diet such as the ketogenic diet, it is also unclear if the type of fats, whether they are saturated, monounsaturated or polyunsaturated, influence the efficacy of the diet. There is also a need to highlight the contribution of the very low carbohydrate-high fat diet on metabolic syndrome comorbidities, such as obesity, dyslipidemia, hypertension, and hyperglycemia.

We are interested in original research or review articles that evaluate the safety and efficacy of low carbohydrate and ketogenic diets for the treatment and prevention of both cancer and metabolic syndrome.
Specifically, we would like to invite submissions with the following themes:
1. The safety and efficacy of low carbohydrate or ketogenic diets on the prevention and treatment of cancer.
2. The safety and efficacy of low carbohydrate or ketogenic diets on metabolic syndrome comorbidities, including obesity, dyslipidemia, hypertension, and hyperglycemia.
3. The role of the type of fat in the efficacy of a low carbohydrate diet on the treatment and prevention of cancer and metabolic syndrome.


Keywords: Cancer, Metabolic Syndrome, Sugar, Ketogenic, Low Carbohydrate Diet


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

The popularity of low carbohydrate diets such as the ketogenic diet has recently soared to an unprecedented level. Historically used to treat epilepsy, ketogenic diets have now been widely adopted to achieve rapid weight loss and promoted to help with diabetes management. As well, since cancer cells typically consume more glucose than normal cells (the Warburg Effect), diets that restrict glucose intake may also help prevent or treat cancer. However, one of the major concerns associated with low carbohydrate, high fat diets such as the ketogenic diets are the effect the diet might have on the lipid profile since it can be high in saturated fats, which is associated with an increased risk of cardiovascular disease.

Many claims regarding the benefits of low carbohydrate diets need to be supported by scientific evidence. More studies are required to highlight the safety and efficacy of such diets for treating cancer and metabolic syndrome. Since no two cancers are identical, there is currently a paucity of information on the effect of glucose restriction in the prevention and treatment of different types of cancer. In a very low carbohydrate high-fat diet such as the ketogenic diet, it is also unclear if the type of fats, whether they are saturated, monounsaturated or polyunsaturated, influence the efficacy of the diet. There is also a need to highlight the contribution of the very low carbohydrate-high fat diet on metabolic syndrome comorbidities, such as obesity, dyslipidemia, hypertension, and hyperglycemia.

We are interested in original research or review articles that evaluate the safety and efficacy of low carbohydrate and ketogenic diets for the treatment and prevention of both cancer and metabolic syndrome.
Specifically, we would like to invite submissions with the following themes:
1. The safety and efficacy of low carbohydrate or ketogenic diets on the prevention and treatment of cancer.
2. The safety and efficacy of low carbohydrate or ketogenic diets on metabolic syndrome comorbidities, including obesity, dyslipidemia, hypertension, and hyperglycemia.
3. The role of the type of fat in the efficacy of a low carbohydrate diet on the treatment and prevention of cancer and metabolic syndrome.


Keywords: Cancer, Metabolic Syndrome, Sugar, Ketogenic, Low Carbohydrate Diet


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

29 June 2020 Abstract
27 October 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

29 June 2020 Abstract
27 October 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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