About this Research Topic
Reactive oxygen species (ROS) play an important role in regulating various physiological functions in organisms. Many studies have demonstrated that an imbalance in redox homeostasis is implicated in both disease initiation and progress. As a result, nanomaterials with unique ROS regulation properties have emerged as a new generation of treatment agents owing to their unique superior advantages. Very recently, nanotherapy-based ROS has been widely used in the treatment of cancer, cerebral infarction, myocardial infarction, and many other diseases.
At present, the research in this field has been mainly focused on the development of nanomaterials with unique characteristics of ROS regulation for guiding the spatiotemporal dynamic behavior of ROS in biological environments. In this Research Topic, we will design different ROS regulation schemes according to the problems of different disease types, mainly focusing on two aspects: First, ROS levels that are too high will lead to aging, damage, and even necrosis of important organs. By employing nanomaterials that can reduce and eliminate ROS, damage to these organs can be greatly reduced; thus they can be used in the treatment of cardiovascular and cerebrovascular diseases, Alzheimer's disease, diabetes, nephritis, and so on. Second, nanomaterials that increase ROS levels can engage the super-oxidation ability of ROS for the treatment of cancer.
As such, we aim to highlight recent advances and developments in ROS-based nanomaterials for biomedical applications. We cordially welcome investigators to submit articles (original research and reviews) that describe the latest techniques in ROS-based nanomaterial synthesis, characterization, and biomedical applications. Potential topics include, but are not limited to:
• Synthesis and characterization of ROS-based nanomaterials
• The rational development of ROS-based nanomaterials for biomedical applications (cancer nanotherapy, bacterial infections, cardiovascular disease, brain disease, etc.)
• The chemistry underlying ROS level depletion by nanomaterials
• The rational design, synthesis, and characterization of ROS-based nanomaterials for biomedical applications
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.